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Intervention Effect of Electroacupuncture Combined with EPCs Transplantation on the Mice in Aging Model
The results of this experiment suggested that electroacupuncture promotes the endothelialization of liver endothelial progenitor cells (EPCs) for mice in D-gal model and improves the repair of vascular endothelial function, as well as increasing the vascular endothelial growth factor (VEGF) expressi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562170/ https://www.ncbi.nlm.nih.gov/pubmed/26379754 http://dx.doi.org/10.1155/2015/972749 |
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author | Wen, Mei |
author_facet | Wen, Mei |
author_sort | Wen, Mei |
collection | PubMed |
description | The results of this experiment suggested that electroacupuncture promotes the endothelialization of liver endothelial progenitor cells (EPCs) for mice in D-gal model and improves the repair of vascular endothelial function, as well as increasing the vascular endothelial growth factor (VEGF) expression in liver tissue fluorescence and KL protein levels. Also, it reduces the malondialdehyde (MDA) activity and delays vascular aging and even overall aging. Results showed that the in vivo fluorescence intensity for D-gal EA group was significantly lower than that of D-gal group, P < 0.05; VEGF fluorescence expression in liver tissue for D-gal EA group was significantly higher than that for D-gal group, P < 0.05; KL protein content in liver tissue for D-gal EA group was significantly higher than that for D-gal group, P < 0.05; MDA activity for D-gal EA group was significantly lower than that for D-gal group, P < 0.05. |
format | Online Article Text |
id | pubmed-4562170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45621702015-09-15 Intervention Effect of Electroacupuncture Combined with EPCs Transplantation on the Mice in Aging Model Wen, Mei Evid Based Complement Alternat Med Research Article The results of this experiment suggested that electroacupuncture promotes the endothelialization of liver endothelial progenitor cells (EPCs) for mice in D-gal model and improves the repair of vascular endothelial function, as well as increasing the vascular endothelial growth factor (VEGF) expression in liver tissue fluorescence and KL protein levels. Also, it reduces the malondialdehyde (MDA) activity and delays vascular aging and even overall aging. Results showed that the in vivo fluorescence intensity for D-gal EA group was significantly lower than that of D-gal group, P < 0.05; VEGF fluorescence expression in liver tissue for D-gal EA group was significantly higher than that for D-gal group, P < 0.05; KL protein content in liver tissue for D-gal EA group was significantly higher than that for D-gal group, P < 0.05; MDA activity for D-gal EA group was significantly lower than that for D-gal group, P < 0.05. Hindawi Publishing Corporation 2015 2015-08-25 /pmc/articles/PMC4562170/ /pubmed/26379754 http://dx.doi.org/10.1155/2015/972749 Text en Copyright © 2015 Mei Wen. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wen, Mei Intervention Effect of Electroacupuncture Combined with EPCs Transplantation on the Mice in Aging Model |
title | Intervention Effect of Electroacupuncture Combined with EPCs Transplantation on the Mice in Aging Model |
title_full | Intervention Effect of Electroacupuncture Combined with EPCs Transplantation on the Mice in Aging Model |
title_fullStr | Intervention Effect of Electroacupuncture Combined with EPCs Transplantation on the Mice in Aging Model |
title_full_unstemmed | Intervention Effect of Electroacupuncture Combined with EPCs Transplantation on the Mice in Aging Model |
title_short | Intervention Effect of Electroacupuncture Combined with EPCs Transplantation on the Mice in Aging Model |
title_sort | intervention effect of electroacupuncture combined with epcs transplantation on the mice in aging model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562170/ https://www.ncbi.nlm.nih.gov/pubmed/26379754 http://dx.doi.org/10.1155/2015/972749 |
work_keys_str_mv | AT wenmei interventioneffectofelectroacupuncturecombinedwithepcstransplantationonthemiceinagingmodel |