Adsorption of Toll-Like Receptor 4 Agonist to Alum-Based Tetanus Toxoid Vaccine Dampens Pro-T Helper 2 Activities and Enhances Antibody Responses

Aluminum salts gels (alum) are TLR-independent adjuvants and have been used to boost antibody responses in alum-based vaccines such as diphtheria, pertussis, and tetanus toxoid (DPT) triple vaccine. However, the pro-Th2 activity of alum-based vaccine formulations has not been fully appreciated. Here...

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Detalles Bibliográficos
Autores principales: Bortolatto, Juliana, Mirotti, Luciana, Rodriguez, Dunia, Gomes, Eliane, Russo, Momtchilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562177/
https://www.ncbi.nlm.nih.gov/pubmed/26380316
http://dx.doi.org/10.1155/2015/280238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562177/
https://www.ncbi.nlm.nih.gov/pubmed/26380316
http://dx.doi.org/10.1155/2015/280238

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