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Low-dose aspirin (acetylsalicylate) prevents increases in brain PGE(2), 15-epi-lipoxin A4 and 8-isoprostane concentrations in 9 month-old HIV-1 transgenic rats, a model for HIV-1 associated neurocognitive disorders

BACKGROUND: Older human immunodeficiency virus (HIV)-1 transgenic rats are a model for HIV-1 associated neurocognitive disorders (HAND). They show behavioral changes, neuroinflammation, neuronal loss, and increased brain arachidonic acid (AA) enzymes. Aspirin (acetylsalicylate, ASA) inhibits AA oxid...

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Detalles Bibliográficos
Autores principales:	Blanchard, Helene C., Taha, Ameer Y., Rapoport, Stanley I, Yuan, Zhi-Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562388/ https://www.ncbi.nlm.nih.gov/pubmed/25638779 http://dx.doi.org/10.1016/j.plefa.2015.01.002

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