Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E

Iron deficiency among endurance athletes is of major concern for coaches, physicians, and nutritionists. Recently, it has been observed that hepcidin, the master regulator of iron metabolism, was upregulated after exercise and was found to be related to interleukin-6 (IL-6) elevation. In this study...

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Autores principales: Díaz, Víctor, Peinado, Ana B, Barba-Moreno, Laura, Altamura, Sandro, Butragueño, Javier, González-Gross, Marcela, Alteheld, Birgit, Stehle, Peter, Zapico, Augusto G, Muckenthaler, Martina U, Gassmann, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562561/
https://www.ncbi.nlm.nih.gov/pubmed/26243212
http://dx.doi.org/10.14814/phy2.12475
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author Díaz, Víctor
Peinado, Ana B
Barba-Moreno, Laura
Altamura, Sandro
Butragueño, Javier
González-Gross, Marcela
Alteheld, Birgit
Stehle, Peter
Zapico, Augusto G
Muckenthaler, Martina U
Gassmann, Max
author_facet Díaz, Víctor
Peinado, Ana B
Barba-Moreno, Laura
Altamura, Sandro
Butragueño, Javier
González-Gross, Marcela
Alteheld, Birgit
Stehle, Peter
Zapico, Augusto G
Muckenthaler, Martina U
Gassmann, Max
author_sort Díaz, Víctor
collection PubMed
description Iron deficiency among endurance athletes is of major concern for coaches, physicians, and nutritionists. Recently, it has been observed that hepcidin, the master regulator of iron metabolism, was upregulated after exercise and was found to be related to interleukin-6 (IL-6) elevation. In this study performed on noniron deficient and well-trained runners, we observed that hepcidin concentrations remain elevated in response to inflammatory and iron signals despite a 28-days supplementation period with vitamins C (500 mg/day) and E (400 IU/day).
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spelling pubmed-45625612015-09-14 Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E Díaz, Víctor Peinado, Ana B Barba-Moreno, Laura Altamura, Sandro Butragueño, Javier González-Gross, Marcela Alteheld, Birgit Stehle, Peter Zapico, Augusto G Muckenthaler, Martina U Gassmann, Max Physiol Rep Original Research Iron deficiency among endurance athletes is of major concern for coaches, physicians, and nutritionists. Recently, it has been observed that hepcidin, the master regulator of iron metabolism, was upregulated after exercise and was found to be related to interleukin-6 (IL-6) elevation. In this study performed on noniron deficient and well-trained runners, we observed that hepcidin concentrations remain elevated in response to inflammatory and iron signals despite a 28-days supplementation period with vitamins C (500 mg/day) and E (400 IU/day). John Wiley & Sons, Ltd 2015-08-04 /pmc/articles/PMC4562561/ /pubmed/26243212 http://dx.doi.org/10.14814/phy2.12475 Text en © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Díaz, Víctor
Peinado, Ana B
Barba-Moreno, Laura
Altamura, Sandro
Butragueño, Javier
González-Gross, Marcela
Alteheld, Birgit
Stehle, Peter
Zapico, Augusto G
Muckenthaler, Martina U
Gassmann, Max
Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E
title Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E
title_full Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E
title_fullStr Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E
title_full_unstemmed Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E
title_short Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E
title_sort elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin c and e
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562561/
https://www.ncbi.nlm.nih.gov/pubmed/26243212
http://dx.doi.org/10.14814/phy2.12475
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