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Seasonal influence over serum and urine metabolic markers in submariners during prolonged patrols

Within the framework of earlier publications, we have consistently dedicated our investigations to eliciting the effects of both seasonal vitamin D deficiency and submarine-induced hypercapnia on serum parameters for acid–base balance and bone metabolism in submariners over a 2-month winter (WP) or...

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Autores principales: Holy, Xavier, Bégot, Laurent, Renault, Sylvie, Butigieg, Xavier, André, Catherine, Bonneau, Dominique, Savourey, Gustave, Collombet, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562580/
https://www.ncbi.nlm.nih.gov/pubmed/26265754
http://dx.doi.org/10.14814/phy2.12494
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author Holy, Xavier
Bégot, Laurent
Renault, Sylvie
Butigieg, Xavier
André, Catherine
Bonneau, Dominique
Savourey, Gustave
Collombet, Jean-Marc
author_facet Holy, Xavier
Bégot, Laurent
Renault, Sylvie
Butigieg, Xavier
André, Catherine
Bonneau, Dominique
Savourey, Gustave
Collombet, Jean-Marc
author_sort Holy, Xavier
collection PubMed
description Within the framework of earlier publications, we have consistently dedicated our investigations to eliciting the effects of both seasonal vitamin D deficiency and submarine-induced hypercapnia on serum parameters for acid–base balance and bone metabolism in submariners over a 2-month winter (WP) or summer (SP) patrols. The latest findings reported herein, contribute further evidence with regard to overall physiological regulations in the same submariner populations that underwent past scrutiny. Hence, urine and blood samples were collected in WP and SP submariners at control prepatrol time as well as on submarine patrol days 20, 41, and 58. Several urine and serum metabolic markers were quantified, namely, deoxypyridinoline (DPD), lactate, albumin, creatinine, nonesterified fatty acids (NEFA), and ionized sodium (Na(+)) or potassium (K(+)), with a view to assessing bone, muscle, liver, or kidney metabolisms. We evidenced bone metabolism alteration (urine DPD, calcium, and phosphorus) previously recorded in submarine crewmembers under prolonged patrols. We also highlighted transitory modifications in liver metabolism (serum albumin) occurring within the first 20 days of submersion. We further evidenced changes in submariners’ renal physiology (serum creatinine) throughout the entire patrol time span. Measurements of ionic homeostasis (serum Na(+) and K(+)) displayed potential seasonal impact over active ionic pumps in submariners. Finally, there is some evidence that submersion provides beneficial conditions prone to fend off seasonal lactic acidosis (serum lactate) detected in WP submariners.
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spelling pubmed-45625802015-09-14 Seasonal influence over serum and urine metabolic markers in submariners during prolonged patrols Holy, Xavier Bégot, Laurent Renault, Sylvie Butigieg, Xavier André, Catherine Bonneau, Dominique Savourey, Gustave Collombet, Jean-Marc Physiol Rep Original Research Within the framework of earlier publications, we have consistently dedicated our investigations to eliciting the effects of both seasonal vitamin D deficiency and submarine-induced hypercapnia on serum parameters for acid–base balance and bone metabolism in submariners over a 2-month winter (WP) or summer (SP) patrols. The latest findings reported herein, contribute further evidence with regard to overall physiological regulations in the same submariner populations that underwent past scrutiny. Hence, urine and blood samples were collected in WP and SP submariners at control prepatrol time as well as on submarine patrol days 20, 41, and 58. Several urine and serum metabolic markers were quantified, namely, deoxypyridinoline (DPD), lactate, albumin, creatinine, nonesterified fatty acids (NEFA), and ionized sodium (Na(+)) or potassium (K(+)), with a view to assessing bone, muscle, liver, or kidney metabolisms. We evidenced bone metabolism alteration (urine DPD, calcium, and phosphorus) previously recorded in submarine crewmembers under prolonged patrols. We also highlighted transitory modifications in liver metabolism (serum albumin) occurring within the first 20 days of submersion. We further evidenced changes in submariners’ renal physiology (serum creatinine) throughout the entire patrol time span. Measurements of ionic homeostasis (serum Na(+) and K(+)) displayed potential seasonal impact over active ionic pumps in submariners. Finally, there is some evidence that submersion provides beneficial conditions prone to fend off seasonal lactic acidosis (serum lactate) detected in WP submariners. John Wiley & Sons, Ltd 2015-08-11 /pmc/articles/PMC4562580/ /pubmed/26265754 http://dx.doi.org/10.14814/phy2.12494 Text en © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Holy, Xavier
Bégot, Laurent
Renault, Sylvie
Butigieg, Xavier
André, Catherine
Bonneau, Dominique
Savourey, Gustave
Collombet, Jean-Marc
Seasonal influence over serum and urine metabolic markers in submariners during prolonged patrols
title Seasonal influence over serum and urine metabolic markers in submariners during prolonged patrols
title_full Seasonal influence over serum and urine metabolic markers in submariners during prolonged patrols
title_fullStr Seasonal influence over serum and urine metabolic markers in submariners during prolonged patrols
title_full_unstemmed Seasonal influence over serum and urine metabolic markers in submariners during prolonged patrols
title_short Seasonal influence over serum and urine metabolic markers in submariners during prolonged patrols
title_sort seasonal influence over serum and urine metabolic markers in submariners during prolonged patrols
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562580/
https://www.ncbi.nlm.nih.gov/pubmed/26265754
http://dx.doi.org/10.14814/phy2.12494
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