Cargando…
Rapid onset vasodilation with single muscle contractions in the leg: influence of age
The influence of aging on contraction-induced rapid vasodilation has been well characterized in the forearm. We sought to examine the impact of aging on contraction-induced rapid vasodilation in the leg following single muscle contractions and determine whether potential age-related impairments were...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562596/ https://www.ncbi.nlm.nih.gov/pubmed/26320213 http://dx.doi.org/10.14814/phy2.12516 |
_version_ | 1782389178150944768 |
---|---|
author | Hughes, William E Ueda, Kenichi Treichler, David P Casey, Darren P |
author_facet | Hughes, William E Ueda, Kenichi Treichler, David P Casey, Darren P |
author_sort | Hughes, William E |
collection | PubMed |
description | The influence of aging on contraction-induced rapid vasodilation has been well characterized in the forearm. We sought to examine the impact of aging on contraction-induced rapid vasodilation in the leg following single muscle contractions and determine whether potential age-related impairments were similar between limbs (leg vs. arm). Fourteen young (23 ± 1 years) and 16 older (66 ± 1 years) adults performed single leg knee extensions at 20%, 40%, and 60% of work rate maximum. Femoral artery diameter and blood velocity were measured using Doppler ultrasound. Limb vascular conductance (VC) was calculated using blood flow (mL·min(−1)) and mean arterial pressure (mmHg). Peak and total vasodilator responses in the leg (change [Δ] in VC from baseline) were blunted in older adults by 44–50% across exercise intensities (P < 0.05 for all). When normalized for muscle mass, age-related differences were still evident (P < 0.05). Comparing the rapid vasodilator responses between the arm and the leg of the same individuals at similar relative intensities (20% and 40%) reveals that aging influences peak and total vasodilation equally between the limbs (no significant age × limb interaction at either intensity, P = 0.28–0.80). Our data demonstrate that (1) older adults exhibit an attenuated rapid hyperemic and vasodilator response in the leg; and (2) the age-related reductions in rapid vasodilation are similar between the arm and the leg. The mechanisms contributing to the age-related differences in contraction-induced rapid vasodilation are perhaps similar to those seen with the forearm model, but have not been confirmed. |
format | Online Article Text |
id | pubmed-4562596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45625962015-09-14 Rapid onset vasodilation with single muscle contractions in the leg: influence of age Hughes, William E Ueda, Kenichi Treichler, David P Casey, Darren P Physiol Rep Original Research The influence of aging on contraction-induced rapid vasodilation has been well characterized in the forearm. We sought to examine the impact of aging on contraction-induced rapid vasodilation in the leg following single muscle contractions and determine whether potential age-related impairments were similar between limbs (leg vs. arm). Fourteen young (23 ± 1 years) and 16 older (66 ± 1 years) adults performed single leg knee extensions at 20%, 40%, and 60% of work rate maximum. Femoral artery diameter and blood velocity were measured using Doppler ultrasound. Limb vascular conductance (VC) was calculated using blood flow (mL·min(−1)) and mean arterial pressure (mmHg). Peak and total vasodilator responses in the leg (change [Δ] in VC from baseline) were blunted in older adults by 44–50% across exercise intensities (P < 0.05 for all). When normalized for muscle mass, age-related differences were still evident (P < 0.05). Comparing the rapid vasodilator responses between the arm and the leg of the same individuals at similar relative intensities (20% and 40%) reveals that aging influences peak and total vasodilation equally between the limbs (no significant age × limb interaction at either intensity, P = 0.28–0.80). Our data demonstrate that (1) older adults exhibit an attenuated rapid hyperemic and vasodilator response in the leg; and (2) the age-related reductions in rapid vasodilation are similar between the arm and the leg. The mechanisms contributing to the age-related differences in contraction-induced rapid vasodilation are perhaps similar to those seen with the forearm model, but have not been confirmed. John Wiley & Sons, Ltd 2015-08-28 /pmc/articles/PMC4562596/ /pubmed/26320213 http://dx.doi.org/10.14814/phy2.12516 Text en © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Hughes, William E Ueda, Kenichi Treichler, David P Casey, Darren P Rapid onset vasodilation with single muscle contractions in the leg: influence of age |
title | Rapid onset vasodilation with single muscle contractions in the leg: influence of age |
title_full | Rapid onset vasodilation with single muscle contractions in the leg: influence of age |
title_fullStr | Rapid onset vasodilation with single muscle contractions in the leg: influence of age |
title_full_unstemmed | Rapid onset vasodilation with single muscle contractions in the leg: influence of age |
title_short | Rapid onset vasodilation with single muscle contractions in the leg: influence of age |
title_sort | rapid onset vasodilation with single muscle contractions in the leg: influence of age |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562596/ https://www.ncbi.nlm.nih.gov/pubmed/26320213 http://dx.doi.org/10.14814/phy2.12516 |
work_keys_str_mv | AT hugheswilliame rapidonsetvasodilationwithsinglemusclecontractionsintheleginfluenceofage AT uedakenichi rapidonsetvasodilationwithsinglemusclecontractionsintheleginfluenceofage AT treichlerdavidp rapidonsetvasodilationwithsinglemusclecontractionsintheleginfluenceofage AT caseydarrenp rapidonsetvasodilationwithsinglemusclecontractionsintheleginfluenceofage |