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Adipokines and the Right Ventricle: The MESA-RV Study
OBJECTIVE: Obesity is associated with changes in both right (RV) and left (LV) ventricular morphology, but the biological basis of this finding is not well established. We examined whether adipokine levels were associated with RV morphology and function in a population-based multiethnic sample free...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562601/ https://www.ncbi.nlm.nih.gov/pubmed/26348768 http://dx.doi.org/10.1371/journal.pone.0136818 |
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author | Harhay, Michael O. Kizer, Jorge R. Criqui, Michael H. Lima, João A. C. Tracy, Russell Bluemke, David A. Kawut, Steven M. |
author_facet | Harhay, Michael O. Kizer, Jorge R. Criqui, Michael H. Lima, João A. C. Tracy, Russell Bluemke, David A. Kawut, Steven M. |
author_sort | Harhay, Michael O. |
collection | PubMed |
description | OBJECTIVE: Obesity is associated with changes in both right (RV) and left (LV) ventricular morphology, but the biological basis of this finding is not well established. We examined whether adipokine levels were associated with RV morphology and function in a population-based multiethnic sample free of clinical cardiovascular disease. METHODS: We examined relationships of leptin, resistin, TNF-α, and adiponectin with RV morphology and function (from cardiac MRI) in participants (n = 1,267) free of clinical cardiovascular disease from the Multi-Ethnic Study of Atherosclerosis (MESA)-RV study. Multivariable regressions (linear, quantile [25(th) and 75(th)] and generalized additive models [GAM]) were used to examine the independent association of each adipokine with RV mass, RV end-diastolic volume (RVEDV), RV end-systolic volume (RVESV), RV stroke volume (RVSV) and RV ejection fraction (RVEF). RESULTS: Higher leptin levels were associated with significantly lower levels of RV mass, RVEDV, RVESV and stroke volume, but not RVEF, after adjustment for age, gender, race, height and weight. These associations were somewhat attenuated but still significant after adjustment for traditional risk factors and covariates, and were completely attenuated when correcting for the respective LV measures. There were no significant interactions of age, gender, or race/ethnicity on the relationship between the four adipokines and RV structure or function. CONCLUSIONS: Leptin levels are associated with favorable RV morphology in a multi-ethnic population free of cardiovascular disease, however these associations may be explained by a yet to be understood bi-ventricular process as this association was no longer present after adjustment for LV values. These findings complement the associations previously shown between adipokines and LV structure and function in both healthy and diseased patients. The mechanisms linking adipokines to healthy cardiovascular function require further investigation. |
format | Online Article Text |
id | pubmed-4562601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45626012015-09-10 Adipokines and the Right Ventricle: The MESA-RV Study Harhay, Michael O. Kizer, Jorge R. Criqui, Michael H. Lima, João A. C. Tracy, Russell Bluemke, David A. Kawut, Steven M. PLoS One Research Article OBJECTIVE: Obesity is associated with changes in both right (RV) and left (LV) ventricular morphology, but the biological basis of this finding is not well established. We examined whether adipokine levels were associated with RV morphology and function in a population-based multiethnic sample free of clinical cardiovascular disease. METHODS: We examined relationships of leptin, resistin, TNF-α, and adiponectin with RV morphology and function (from cardiac MRI) in participants (n = 1,267) free of clinical cardiovascular disease from the Multi-Ethnic Study of Atherosclerosis (MESA)-RV study. Multivariable regressions (linear, quantile [25(th) and 75(th)] and generalized additive models [GAM]) were used to examine the independent association of each adipokine with RV mass, RV end-diastolic volume (RVEDV), RV end-systolic volume (RVESV), RV stroke volume (RVSV) and RV ejection fraction (RVEF). RESULTS: Higher leptin levels were associated with significantly lower levels of RV mass, RVEDV, RVESV and stroke volume, but not RVEF, after adjustment for age, gender, race, height and weight. These associations were somewhat attenuated but still significant after adjustment for traditional risk factors and covariates, and were completely attenuated when correcting for the respective LV measures. There were no significant interactions of age, gender, or race/ethnicity on the relationship between the four adipokines and RV structure or function. CONCLUSIONS: Leptin levels are associated with favorable RV morphology in a multi-ethnic population free of cardiovascular disease, however these associations may be explained by a yet to be understood bi-ventricular process as this association was no longer present after adjustment for LV values. These findings complement the associations previously shown between adipokines and LV structure and function in both healthy and diseased patients. The mechanisms linking adipokines to healthy cardiovascular function require further investigation. Public Library of Science 2015-09-08 /pmc/articles/PMC4562601/ /pubmed/26348768 http://dx.doi.org/10.1371/journal.pone.0136818 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Harhay, Michael O. Kizer, Jorge R. Criqui, Michael H. Lima, João A. C. Tracy, Russell Bluemke, David A. Kawut, Steven M. Adipokines and the Right Ventricle: The MESA-RV Study |
title | Adipokines and the Right Ventricle: The MESA-RV Study |
title_full | Adipokines and the Right Ventricle: The MESA-RV Study |
title_fullStr | Adipokines and the Right Ventricle: The MESA-RV Study |
title_full_unstemmed | Adipokines and the Right Ventricle: The MESA-RV Study |
title_short | Adipokines and the Right Ventricle: The MESA-RV Study |
title_sort | adipokines and the right ventricle: the mesa-rv study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562601/ https://www.ncbi.nlm.nih.gov/pubmed/26348768 http://dx.doi.org/10.1371/journal.pone.0136818 |
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