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The Importance of Neighborhood Scheme Selection in Agent-based Tumor Growth Modeling
Modeling tumor growth has proven a very challenging problem, mainly due to the fact that tumors are highly complex systems that involve dynamic interactions spanning multiple scales both in time and space. The desire to describe interactions in various scales has given rise to modeling approaches th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562677/ https://www.ncbi.nlm.nih.gov/pubmed/26396490 http://dx.doi.org/10.4137/CIN.S19343 |
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author | Tzedakis, Georgios Tzamali, Eleftheria Marias, Kostas Sakkalis, Vangelis |
author_facet | Tzedakis, Georgios Tzamali, Eleftheria Marias, Kostas Sakkalis, Vangelis |
author_sort | Tzedakis, Georgios |
collection | PubMed |
description | Modeling tumor growth has proven a very challenging problem, mainly due to the fact that tumors are highly complex systems that involve dynamic interactions spanning multiple scales both in time and space. The desire to describe interactions in various scales has given rise to modeling approaches that use both continuous and discrete variables, known as hybrid approaches. This work refers to a hybrid model on a 2D square lattice focusing on cell movement dynamics as they play an important role in tumor morphology, invasion and metastasis and are considered as indicators for the stage of malignancy used for early prognosis and effective treatment. Considering various distributions of the microenvironment, we explore how Neumann vs. Moore neighborhood schemes affects tumor growth and morphology. The results indicate that the importance of neighborhood selection is critical under specific conditions that include i) increased hapto/chemo-tactic coefficient, ii) a rugged microenvironment and iii) ECM degradation. |
format | Online Article Text |
id | pubmed-4562677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-45626772015-09-22 The Importance of Neighborhood Scheme Selection in Agent-based Tumor Growth Modeling Tzedakis, Georgios Tzamali, Eleftheria Marias, Kostas Sakkalis, Vangelis Cancer Inform Original Research Modeling tumor growth has proven a very challenging problem, mainly due to the fact that tumors are highly complex systems that involve dynamic interactions spanning multiple scales both in time and space. The desire to describe interactions in various scales has given rise to modeling approaches that use both continuous and discrete variables, known as hybrid approaches. This work refers to a hybrid model on a 2D square lattice focusing on cell movement dynamics as they play an important role in tumor morphology, invasion and metastasis and are considered as indicators for the stage of malignancy used for early prognosis and effective treatment. Considering various distributions of the microenvironment, we explore how Neumann vs. Moore neighborhood schemes affects tumor growth and morphology. The results indicate that the importance of neighborhood selection is critical under specific conditions that include i) increased hapto/chemo-tactic coefficient, ii) a rugged microenvironment and iii) ECM degradation. Libertas Academica 2015-09-07 /pmc/articles/PMC4562677/ /pubmed/26396490 http://dx.doi.org/10.4137/CIN.S19343 Text en © 2015 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Original Research Tzedakis, Georgios Tzamali, Eleftheria Marias, Kostas Sakkalis, Vangelis The Importance of Neighborhood Scheme Selection in Agent-based Tumor Growth Modeling |
title | The Importance of Neighborhood Scheme Selection in Agent-based Tumor Growth Modeling |
title_full | The Importance of Neighborhood Scheme Selection in Agent-based Tumor Growth Modeling |
title_fullStr | The Importance of Neighborhood Scheme Selection in Agent-based Tumor Growth Modeling |
title_full_unstemmed | The Importance of Neighborhood Scheme Selection in Agent-based Tumor Growth Modeling |
title_short | The Importance of Neighborhood Scheme Selection in Agent-based Tumor Growth Modeling |
title_sort | importance of neighborhood scheme selection in agent-based tumor growth modeling |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562677/ https://www.ncbi.nlm.nih.gov/pubmed/26396490 http://dx.doi.org/10.4137/CIN.S19343 |
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