Tethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase

Disassembly of the Cdc45-MCM-GINS (CMG) DNA helicase, which unwinds the parental DNA duplex at eukaryotic replication forks, is the key regulated step during replication termination but is poorly understood [1, 2]. In budding yeast, the F-box protein Dia2 drives ubiquitylation of the CMG helicase at...

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Detalles Bibliográficos
Autores principales: Maculins, Timurs, Nkosi, Pedro Junior, Nishikawa, Hiroko, Labib, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562905/
https://www.ncbi.nlm.nih.gov/pubmed/26255844
http://dx.doi.org/10.1016/j.cub.2015.07.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562905/
https://www.ncbi.nlm.nih.gov/pubmed/26255844
http://dx.doi.org/10.1016/j.cub.2015.07.012

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