Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest

Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently accompanied by multinucleation; however, the origin of this is unknown. Here, we show that multinucleate OIS cells originate mostly from failed mito...

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Detalles Bibliográficos
Autores principales: Dikovskaya, Dina, Cole, John J., Mason, Susan M., Nixon, Colin, Karim, Saadia A., McGarry, Lynn, Clark, William, Hewitt, Rachael N., Sammons, Morgan A., Zhu, Jiajun, Athineos, Dimitris, Leach, Joshua D.G., Marchesi, Francesco, van Tuyn, John, Tait, Stephen W., Brock, Claire, Morton, Jennifer P., Wu, Hong, Berger, Shelley L., Blyth, Karen, Adams, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562906/
https://www.ncbi.nlm.nih.gov/pubmed/26299965
http://dx.doi.org/10.1016/j.celrep.2015.07.055

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