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Circulating Levels of PAI-1 and SERPINE1 4G/4G Polymorphism Are Predictive of Poor Prognosis in HCC Patients Undergoing TACE()
Although several molecular markers have been proposed as prognostic of disease progression in Hepatocellular carcinoma (HCC), predictive markers of response to treatment are still unsatisfactory. Here, we propose a genetic polymorphism as a potential predictive factor of poor prognosis in HCC patien...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562977/ https://www.ncbi.nlm.nih.gov/pubmed/26310373 http://dx.doi.org/10.1016/j.tranon.2015.05.002 |
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author | Divella, Rosa Daniele, Antonella Abbate, Ines Savino, Eufemia Casamassima, Porzia Sciortino, Giancarlo Simone, Giovanni Gadaleta-Caldarola, Gennaro Fazio, Vito Gadaleta, Cosimo Damiano Sabbà, Carlo Mazzocca, Antonio |
author_facet | Divella, Rosa Daniele, Antonella Abbate, Ines Savino, Eufemia Casamassima, Porzia Sciortino, Giancarlo Simone, Giovanni Gadaleta-Caldarola, Gennaro Fazio, Vito Gadaleta, Cosimo Damiano Sabbà, Carlo Mazzocca, Antonio |
author_sort | Divella, Rosa |
collection | PubMed |
description | Although several molecular markers have been proposed as prognostic of disease progression in Hepatocellular carcinoma (HCC), predictive markers of response to treatment are still unsatisfactory. Here, we propose a genetic polymorphism as a potential predictive factor of poor prognosis in HCC patients treated with transcatheter arterial chemoembolization (TACE). In particular, we show that the guanosine insertion/deletion polymorphism in the promoter region of SERPINE1 gene at the − 675 bp position, named 4G/4G, predicts poor prognosis in a cohort of 75 patients with HCC undergoing TACE. By a combination of ELISA and SERPINE1 promoter study, we found that the presence of elevated plasma levels of plasminogen activator inhibitor-1 (PAI-1) in patients with 4G/4G genotype is significantly associated with reduced overall survival compared to patients with 5G/5G or 4G/5G genotype in HCC patients after TACE. Our analysis provided evidence that variation in SERPINE1 gene plays a role in defining the outcome in patients treated with TACE. In addition to a poor disease outcome, the 4G/4G variant represents an unfavorable predictive factor for response to chemotherapy as well. |
format | Online Article Text |
id | pubmed-4562977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45629772015-09-29 Circulating Levels of PAI-1 and SERPINE1 4G/4G Polymorphism Are Predictive of Poor Prognosis in HCC Patients Undergoing TACE() Divella, Rosa Daniele, Antonella Abbate, Ines Savino, Eufemia Casamassima, Porzia Sciortino, Giancarlo Simone, Giovanni Gadaleta-Caldarola, Gennaro Fazio, Vito Gadaleta, Cosimo Damiano Sabbà, Carlo Mazzocca, Antonio Transl Oncol Article Although several molecular markers have been proposed as prognostic of disease progression in Hepatocellular carcinoma (HCC), predictive markers of response to treatment are still unsatisfactory. Here, we propose a genetic polymorphism as a potential predictive factor of poor prognosis in HCC patients treated with transcatheter arterial chemoembolization (TACE). In particular, we show that the guanosine insertion/deletion polymorphism in the promoter region of SERPINE1 gene at the − 675 bp position, named 4G/4G, predicts poor prognosis in a cohort of 75 patients with HCC undergoing TACE. By a combination of ELISA and SERPINE1 promoter study, we found that the presence of elevated plasma levels of plasminogen activator inhibitor-1 (PAI-1) in patients with 4G/4G genotype is significantly associated with reduced overall survival compared to patients with 5G/5G or 4G/5G genotype in HCC patients after TACE. Our analysis provided evidence that variation in SERPINE1 gene plays a role in defining the outcome in patients treated with TACE. In addition to a poor disease outcome, the 4G/4G variant represents an unfavorable predictive factor for response to chemotherapy as well. Neoplasia Press 2015-08-24 /pmc/articles/PMC4562977/ /pubmed/26310373 http://dx.doi.org/10.1016/j.tranon.2015.05.002 Text en © 2015 The Authors. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Divella, Rosa Daniele, Antonella Abbate, Ines Savino, Eufemia Casamassima, Porzia Sciortino, Giancarlo Simone, Giovanni Gadaleta-Caldarola, Gennaro Fazio, Vito Gadaleta, Cosimo Damiano Sabbà, Carlo Mazzocca, Antonio Circulating Levels of PAI-1 and SERPINE1 4G/4G Polymorphism Are Predictive of Poor Prognosis in HCC Patients Undergoing TACE() |
title | Circulating Levels of PAI-1 and SERPINE1 4G/4G Polymorphism Are Predictive of Poor Prognosis in HCC Patients Undergoing TACE() |
title_full | Circulating Levels of PAI-1 and SERPINE1 4G/4G Polymorphism Are Predictive of Poor Prognosis in HCC Patients Undergoing TACE() |
title_fullStr | Circulating Levels of PAI-1 and SERPINE1 4G/4G Polymorphism Are Predictive of Poor Prognosis in HCC Patients Undergoing TACE() |
title_full_unstemmed | Circulating Levels of PAI-1 and SERPINE1 4G/4G Polymorphism Are Predictive of Poor Prognosis in HCC Patients Undergoing TACE() |
title_short | Circulating Levels of PAI-1 and SERPINE1 4G/4G Polymorphism Are Predictive of Poor Prognosis in HCC Patients Undergoing TACE() |
title_sort | circulating levels of pai-1 and serpine1 4g/4g polymorphism are predictive of poor prognosis in hcc patients undergoing tace() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562977/ https://www.ncbi.nlm.nih.gov/pubmed/26310373 http://dx.doi.org/10.1016/j.tranon.2015.05.002 |
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