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Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity

In the present study behavioral effects of the 5-HT(2C) serotonin receptor were investigated in different mouse strains. The 5-HT(2C) receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice. This effec...

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Autores principales: Bazovkina, Darya V., Kondaurova, Elena M., Naumenko, Vladimir S., Ponimaskin, Evgeni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563107/
https://www.ncbi.nlm.nih.gov/pubmed/26380122
http://dx.doi.org/10.1155/2015/846589
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author Bazovkina, Darya V.
Kondaurova, Elena M.
Naumenko, Vladimir S.
Ponimaskin, Evgeni
author_facet Bazovkina, Darya V.
Kondaurova, Elena M.
Naumenko, Vladimir S.
Ponimaskin, Evgeni
author_sort Bazovkina, Darya V.
collection PubMed
description In the present study behavioral effects of the 5-HT(2C) serotonin receptor were investigated in different mouse strains. The 5-HT(2C) receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice. This effect was receptor-specific because it was inhibited by the 5-HT(2C) receptor antagonist RS102221. To study the role of genotype in 5-HT(2C) receptor-induced hypolocomotion, locomotor activity of seven inbred mouse strains was measured after MK-212 acute treatment. We found that the 5-HT(2C) receptor stimulation by MK-212 decreased distance traveled in the open field test in CBA/Lac, C57Bl/6, C3H/He, and ICR mice, whereas it failed to affect locomotor activity in DBA/2J, Asn, and Balb/c mice. We also compared the interstrain differences in functional response to 5-HT(2C) and 5-HT(2A) receptors activation measured by the quantification of receptor-mediated head-twitches. These experiments revealed significant positive correlation between 5-HT2C and 5-HT2A receptors functional responses for all investigated mouse strains. Moreover, we found that 5-HT(2A) receptor activation with DOI did not change locomotor activity in CBA/Lac mice. Taken together, our data indicate the implication of 5-HT(2C) receptors in regulation of locomotor activity and suggest the shared mechanism for functional responses mediated by 5-HT(2C) and 5-HT(2A) receptors.
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spelling pubmed-45631072015-09-16 Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity Bazovkina, Darya V. Kondaurova, Elena M. Naumenko, Vladimir S. Ponimaskin, Evgeni Neural Plast Research Article In the present study behavioral effects of the 5-HT(2C) serotonin receptor were investigated in different mouse strains. The 5-HT(2C) receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice. This effect was receptor-specific because it was inhibited by the 5-HT(2C) receptor antagonist RS102221. To study the role of genotype in 5-HT(2C) receptor-induced hypolocomotion, locomotor activity of seven inbred mouse strains was measured after MK-212 acute treatment. We found that the 5-HT(2C) receptor stimulation by MK-212 decreased distance traveled in the open field test in CBA/Lac, C57Bl/6, C3H/He, and ICR mice, whereas it failed to affect locomotor activity in DBA/2J, Asn, and Balb/c mice. We also compared the interstrain differences in functional response to 5-HT(2C) and 5-HT(2A) receptors activation measured by the quantification of receptor-mediated head-twitches. These experiments revealed significant positive correlation between 5-HT2C and 5-HT2A receptors functional responses for all investigated mouse strains. Moreover, we found that 5-HT(2A) receptor activation with DOI did not change locomotor activity in CBA/Lac mice. Taken together, our data indicate the implication of 5-HT(2C) receptors in regulation of locomotor activity and suggest the shared mechanism for functional responses mediated by 5-HT(2C) and 5-HT(2A) receptors. Hindawi Publishing Corporation 2015 2015-08-26 /pmc/articles/PMC4563107/ /pubmed/26380122 http://dx.doi.org/10.1155/2015/846589 Text en Copyright © 2015 Darya V. Bazovkina et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bazovkina, Darya V.
Kondaurova, Elena M.
Naumenko, Vladimir S.
Ponimaskin, Evgeni
Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity
title Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity
title_full Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity
title_fullStr Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity
title_full_unstemmed Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity
title_short Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity
title_sort genotype-dependent difference in 5-ht(2c) receptor-induced hypolocomotion: comparison with 5-ht(2a) receptor functional activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563107/
https://www.ncbi.nlm.nih.gov/pubmed/26380122
http://dx.doi.org/10.1155/2015/846589
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