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Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity
In the present study behavioral effects of the 5-HT(2C) serotonin receptor were investigated in different mouse strains. The 5-HT(2C) receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice. This effec...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563107/ https://www.ncbi.nlm.nih.gov/pubmed/26380122 http://dx.doi.org/10.1155/2015/846589 |
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author | Bazovkina, Darya V. Kondaurova, Elena M. Naumenko, Vladimir S. Ponimaskin, Evgeni |
author_facet | Bazovkina, Darya V. Kondaurova, Elena M. Naumenko, Vladimir S. Ponimaskin, Evgeni |
author_sort | Bazovkina, Darya V. |
collection | PubMed |
description | In the present study behavioral effects of the 5-HT(2C) serotonin receptor were investigated in different mouse strains. The 5-HT(2C) receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice. This effect was receptor-specific because it was inhibited by the 5-HT(2C) receptor antagonist RS102221. To study the role of genotype in 5-HT(2C) receptor-induced hypolocomotion, locomotor activity of seven inbred mouse strains was measured after MK-212 acute treatment. We found that the 5-HT(2C) receptor stimulation by MK-212 decreased distance traveled in the open field test in CBA/Lac, C57Bl/6, C3H/He, and ICR mice, whereas it failed to affect locomotor activity in DBA/2J, Asn, and Balb/c mice. We also compared the interstrain differences in functional response to 5-HT(2C) and 5-HT(2A) receptors activation measured by the quantification of receptor-mediated head-twitches. These experiments revealed significant positive correlation between 5-HT2C and 5-HT2A receptors functional responses for all investigated mouse strains. Moreover, we found that 5-HT(2A) receptor activation with DOI did not change locomotor activity in CBA/Lac mice. Taken together, our data indicate the implication of 5-HT(2C) receptors in regulation of locomotor activity and suggest the shared mechanism for functional responses mediated by 5-HT(2C) and 5-HT(2A) receptors. |
format | Online Article Text |
id | pubmed-4563107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45631072015-09-16 Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity Bazovkina, Darya V. Kondaurova, Elena M. Naumenko, Vladimir S. Ponimaskin, Evgeni Neural Plast Research Article In the present study behavioral effects of the 5-HT(2C) serotonin receptor were investigated in different mouse strains. The 5-HT(2C) receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice. This effect was receptor-specific because it was inhibited by the 5-HT(2C) receptor antagonist RS102221. To study the role of genotype in 5-HT(2C) receptor-induced hypolocomotion, locomotor activity of seven inbred mouse strains was measured after MK-212 acute treatment. We found that the 5-HT(2C) receptor stimulation by MK-212 decreased distance traveled in the open field test in CBA/Lac, C57Bl/6, C3H/He, and ICR mice, whereas it failed to affect locomotor activity in DBA/2J, Asn, and Balb/c mice. We also compared the interstrain differences in functional response to 5-HT(2C) and 5-HT(2A) receptors activation measured by the quantification of receptor-mediated head-twitches. These experiments revealed significant positive correlation between 5-HT2C and 5-HT2A receptors functional responses for all investigated mouse strains. Moreover, we found that 5-HT(2A) receptor activation with DOI did not change locomotor activity in CBA/Lac mice. Taken together, our data indicate the implication of 5-HT(2C) receptors in regulation of locomotor activity and suggest the shared mechanism for functional responses mediated by 5-HT(2C) and 5-HT(2A) receptors. Hindawi Publishing Corporation 2015 2015-08-26 /pmc/articles/PMC4563107/ /pubmed/26380122 http://dx.doi.org/10.1155/2015/846589 Text en Copyright © 2015 Darya V. Bazovkina et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bazovkina, Darya V. Kondaurova, Elena M. Naumenko, Vladimir S. Ponimaskin, Evgeni Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity |
title | Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity |
title_full | Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity |
title_fullStr | Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity |
title_full_unstemmed | Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity |
title_short | Genotype-Dependent Difference in 5-HT(2C) Receptor-Induced Hypolocomotion: Comparison with 5-HT(2A) Receptor Functional Activity |
title_sort | genotype-dependent difference in 5-ht(2c) receptor-induced hypolocomotion: comparison with 5-ht(2a) receptor functional activity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563107/ https://www.ncbi.nlm.nih.gov/pubmed/26380122 http://dx.doi.org/10.1155/2015/846589 |
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