DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18(INK4C) in gastric carcinogenesis

Little is known about the roles of DNA methyltransferase 3A (DNMT3A) in gastric carcinogenesis. Here, we reported that the exogenous expression of DNMT3A promoted gastric cancer (GC) cell proliferation by accelerating the G1/S transition. Subsequently, p18(INK4C) was identified as a downstream targe...

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Detalles Bibliográficos
Autores principales: Cui, He, Zhao, Chengcheng, Gong, Pihai, Wang, Ling, Wu, Huazhang, Zhang, Kun, Zhou, Rongping, Wang, Li, Zhang, Ting, Zhong, Sheng, Fan, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563369/
https://www.ncbi.nlm.nih.gov/pubmed/26350239
http://dx.doi.org/10.1038/srep13781

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