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Photo-activatable Cre recombinase regulates gene expression in vivo

Techniques allowing precise spatial and temporal control of gene expression in the brain are needed. Herein we describe optogenetic approaches using a photo-activatable Cre recombinase (PA-Cre) to stably modify gene expression in the mouse brain. Blue light illumination for 12 hours via optical fibe...

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Detalles Bibliográficos
Autores principales:	Schindler, Suzanne E., McCall, Jordan G., Yan, Ping, Hyrc, Krzystof L., Li, Mingjie, Tucker, Chandra L., Lee, Jin-Moo, Bruchas, Michael R., Diamond, Marc I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563371/ https://www.ncbi.nlm.nih.gov/pubmed/26350769 http://dx.doi.org/10.1038/srep13627

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