Ultraviolet light triggers the conversion of Cu(2+)-bound Aβ(42) aggregates into cytotoxic species in a copper chelation-independent manner

Increasing evidence indicates that abnormal Cu(2+) binding to Aβ peptides are responsible for the formation of soluble Aβ oligomers and ROS that play essential roles in AD pathogenesis. During studying the Cu(2+)-chelating treatment of Cu(2+)-bound Aβ(42) aggregates, we found that UV light exposure...

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Detalles Bibliográficos
Autores principales: Dong, Xiongwei, Zhang, Zhe, Zhao, Dan, Liu, Yaojing, Meng, Yan, Zhang, Yong, Zhang, Dan, Liu, Changlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563556/
https://www.ncbi.nlm.nih.gov/pubmed/26350232
http://dx.doi.org/10.1038/srep13897

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