Characterization of the Tyrosine Kinase-Regulated Proteome in Breast Cancer by Combined use of RNA interference (RNAi) and Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) Quantitative Proteomics

Tyrosine kinases (TKs) are central regulators in cellular activities and perturbations of TK signaling contribute to oncogenesis. However, less than half of the TKs have been thoroughly studied and a global functional analysis of their proteomic portrait is lacking. Here we conducted a combined appr...

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Detalles Bibliográficos
Autores principales: Stebbing, Justin, Zhang, Hua, Xu, Yichen, Grothey, Arnhild, Ajuh, Paul, Angelopoulos, Nicos, Giamas, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2015
Materias:
Regular Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563730/
https://www.ncbi.nlm.nih.gov/pubmed/26089344
http://dx.doi.org/10.1074/mcp.M115.048090

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