Reversible DNA i-motif to hairpin switching induced by copper(ii) cations

i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(ii) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by ch...

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Detalles Bibliográficos
Autores principales: Day, Henry Albert, Wright, Elisé Patricia, MacDonald, Colin John, Gates, Andrew James, Waller, Zoë Ann Ella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563791/
https://www.ncbi.nlm.nih.gov/pubmed/26252811
http://dx.doi.org/10.1039/c5cc05111h
Descripción
Sumario:i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(ii) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.

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