Reversible DNA i-motif to hairpin switching induced by copper(ii) cations

i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(ii) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by ch...

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Detalles Bibliográficos
Autores principales: Day, Henry Albert, Wright, Elisé Patricia, MacDonald, Colin John, Gates, Andrew James, Waller, Zoë Ann Ella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563791/
https://www.ncbi.nlm.nih.gov/pubmed/26252811
http://dx.doi.org/10.1039/c5cc05111h
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author Day, Henry Albert
Wright, Elisé Patricia
MacDonald, Colin John
Gates, Andrew James
Waller, Zoë Ann Ella
author_facet Day, Henry Albert
Wright, Elisé Patricia
MacDonald, Colin John
Gates, Andrew James
Waller, Zoë Ann Ella
author_sort Day, Henry Albert
collection PubMed
description i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(ii) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.
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spelling pubmed-45637912015-09-29 Reversible DNA i-motif to hairpin switching induced by copper(ii) cations Day, Henry Albert Wright, Elisé Patricia MacDonald, Colin John Gates, Andrew James Waller, Zoë Ann Ella Chem Commun (Camb) Chemistry i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(ii) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA. Royal Society of Chemistry 2015-09-25 2015-08-07 /pmc/articles/PMC4563791/ /pubmed/26252811 http://dx.doi.org/10.1039/c5cc05111h Text en This journal is © The Royal Society of Chemistry 2015 https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Day, Henry Albert
Wright, Elisé Patricia
MacDonald, Colin John
Gates, Andrew James
Waller, Zoë Ann Ella
Reversible DNA i-motif to hairpin switching induced by copper(ii) cations
title Reversible DNA i-motif to hairpin switching induced by copper(ii) cations
title_full Reversible DNA i-motif to hairpin switching induced by copper(ii) cations
title_fullStr Reversible DNA i-motif to hairpin switching induced by copper(ii) cations
title_full_unstemmed Reversible DNA i-motif to hairpin switching induced by copper(ii) cations
title_short Reversible DNA i-motif to hairpin switching induced by copper(ii) cations
title_sort reversible dna i-motif to hairpin switching induced by copper(ii) cations
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563791/
https://www.ncbi.nlm.nih.gov/pubmed/26252811
http://dx.doi.org/10.1039/c5cc05111h
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