Cargando…
A comparison of intranasal ketamine and intranasal midazolam for pediatric premedication
AIMS AND OBJECTIVES: The aim of our study is to compare the efficacy and side-effects of Ketamine and Midazolam administered nasally for the pediatric premedication. MATERIALS AND METHODS: We studied 100 American Society of Anesthesiology I and II children aged from 1 to 10 years undergoing various...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563959/ https://www.ncbi.nlm.nih.gov/pubmed/26417129 http://dx.doi.org/10.4103/0259-1162.154051 |
_version_ | 1782389356321832960 |
---|---|
author | Narendra, P. L. Naphade, Ramesh W. Nallamilli, Samson Mohd, Shanawaz |
author_facet | Narendra, P. L. Naphade, Ramesh W. Nallamilli, Samson Mohd, Shanawaz |
author_sort | Narendra, P. L. |
collection | PubMed |
description | AIMS AND OBJECTIVES: The aim of our study is to compare the efficacy and side-effects of Ketamine and Midazolam administered nasally for the pediatric premedication. MATERIALS AND METHODS: We studied 100 American Society of Anesthesiology I and II children aged from 1 to 10 years undergoing various surgical procedures. Totally, 50 children were evaluated for nasal ketamine (using 50 mg/ml vials) at the dose of 5 mg/kg and the other 50 received nasal midazolam 0.2 mg/kg, before induction in operation theater each patient was observed for onset of sedation, degree of sedation, emotional status being recorded with a five point sedation scale, response to venipuncture and acceptance of mask, whether readily, with persuasion or refuse. RESULTS: The two groups were homogenous. Midazolam showed a statistically significant early onset of sedation (10.76 ± 2.0352 vs. 16.42 ± 2.0696 min). There were no significant differences in venipuncture score, sedation scale at 20 min, acceptance of mask and oxygen saturation throughout the study. Significant tachycardia and ‘secretions were observed in the ketamine group intra operatively. Postoperatively emergence (8% vs. 0%) and secretions (28% vs. 4%) were significant in the ketamine group. Nausea and vomiting occurred in l6% versus 10% for midazolam and ketamine group. CONCLUSIONS: Both midazolam and ketamine nasally are an effective pediatric premedication. Midazolam has an early onset of sedation and is associated with fewer side-effects. |
format | Online Article Text |
id | pubmed-4563959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45639592015-09-28 A comparison of intranasal ketamine and intranasal midazolam for pediatric premedication Narendra, P. L. Naphade, Ramesh W. Nallamilli, Samson Mohd, Shanawaz Anesth Essays Res Original Article AIMS AND OBJECTIVES: The aim of our study is to compare the efficacy and side-effects of Ketamine and Midazolam administered nasally for the pediatric premedication. MATERIALS AND METHODS: We studied 100 American Society of Anesthesiology I and II children aged from 1 to 10 years undergoing various surgical procedures. Totally, 50 children were evaluated for nasal ketamine (using 50 mg/ml vials) at the dose of 5 mg/kg and the other 50 received nasal midazolam 0.2 mg/kg, before induction in operation theater each patient was observed for onset of sedation, degree of sedation, emotional status being recorded with a five point sedation scale, response to venipuncture and acceptance of mask, whether readily, with persuasion or refuse. RESULTS: The two groups were homogenous. Midazolam showed a statistically significant early onset of sedation (10.76 ± 2.0352 vs. 16.42 ± 2.0696 min). There were no significant differences in venipuncture score, sedation scale at 20 min, acceptance of mask and oxygen saturation throughout the study. Significant tachycardia and ‘secretions were observed in the ketamine group intra operatively. Postoperatively emergence (8% vs. 0%) and secretions (28% vs. 4%) were significant in the ketamine group. Nausea and vomiting occurred in l6% versus 10% for midazolam and ketamine group. CONCLUSIONS: Both midazolam and ketamine nasally are an effective pediatric premedication. Midazolam has an early onset of sedation and is associated with fewer side-effects. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4563959/ /pubmed/26417129 http://dx.doi.org/10.4103/0259-1162.154051 Text en Copyright: © Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Narendra, P. L. Naphade, Ramesh W. Nallamilli, Samson Mohd, Shanawaz A comparison of intranasal ketamine and intranasal midazolam for pediatric premedication |
title | A comparison of intranasal ketamine and intranasal midazolam for pediatric premedication |
title_full | A comparison of intranasal ketamine and intranasal midazolam for pediatric premedication |
title_fullStr | A comparison of intranasal ketamine and intranasal midazolam for pediatric premedication |
title_full_unstemmed | A comparison of intranasal ketamine and intranasal midazolam for pediatric premedication |
title_short | A comparison of intranasal ketamine and intranasal midazolam for pediatric premedication |
title_sort | comparison of intranasal ketamine and intranasal midazolam for pediatric premedication |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563959/ https://www.ncbi.nlm.nih.gov/pubmed/26417129 http://dx.doi.org/10.4103/0259-1162.154051 |
work_keys_str_mv | AT narendrapl acomparisonofintranasalketamineandintranasalmidazolamforpediatricpremedication AT naphaderameshw acomparisonofintranasalketamineandintranasalmidazolamforpediatricpremedication AT nallamillisamson acomparisonofintranasalketamineandintranasalmidazolamforpediatricpremedication AT mohdshanawaz acomparisonofintranasalketamineandintranasalmidazolamforpediatricpremedication AT narendrapl comparisonofintranasalketamineandintranasalmidazolamforpediatricpremedication AT naphaderameshw comparisonofintranasalketamineandintranasalmidazolamforpediatricpremedication AT nallamillisamson comparisonofintranasalketamineandintranasalmidazolamforpediatricpremedication AT mohdshanawaz comparisonofintranasalketamineandintranasalmidazolamforpediatricpremedication |