Cargando…

Differential crosstalk between the AMPK and PI3K/Akt pathways in breast cancer cells of differing genotypes: Leptin inhibits the effectiveness of AMPK activation

AMP-activated protein kinase (AMPK), a sensor of cellular energy, is widely reported as a potential therapeutic target in treatment of breast and other cancers. The activated enzyme has been shown to be a promising anti-proliferative agent in breast cancer cell lines. However, little data exist on c...

Descripción completa

Detalles Bibliográficos
Autores principales:	EL-MASRY, OMAR S., AL-SAKKAf, KALTOOM, BROWN, BARRY L., DOBSON, PAULINE R.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564084/ https://www.ncbi.nlm.nih.gov/pubmed/26260992 http://dx.doi.org/10.3892/or.2015.4198

Ejemplares similares

AMPK Activation of Apoptotic Markers in Human Breast Cancer Cell Lines with Different p53 Backgrounds: MCF-7, MDA-MB-231 and T47D Cells
por: El-Masry, Omar S, et al.
Publicado: (2019)

Immunohistochemical staining of leptin is associated with grade, stage, lymph node involvement, recurrence, and hormone receptor phenotypes in breast cancer
por: Khabaz, Mohamad Nidal, et al.
Publicado: (2017)

Antidiabetic Effect of Artemether in Db/Db Mice Involves Regulation of AMPK and PI3K/Akt Pathways
por: Bai, Xiaolin, et al.
Publicado: (2020)

Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway
por: Liu, Na, et al.
Publicado: (2020)

AMPK exerts dual regulatory effects on the PI3K pathway
por: Tao, Rong, et al.
Publicado: (2010)

Glucose Enhances Leptin Signaling through Modulation of AMPK Activity
por: Su, Haoran, et al.
Publicado: (2012)

Caffeic Acid Derivatives Inhibit the Growth of Colon Cancer: Involvement of the PI3-K/Akt and AMPK Signaling Pathways
por: Chiang, En-Pei Isabel, et al.
Publicado: (2014)

Chloroquine increases phosphorylation of AMPK and Akt in myotubes
por: Spears, Larry D., et al.
Publicado: (2016)

Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways
por: Mazibuko-Mbeje, Sithandiwe E., et al.
Publicado: (2019)

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways
por: Chen, Xubo, et al.
Publicado: (2017)

Central Exercise Action Increases the AMPK and mTOR Response to Leptin
por: Ropelle, Eduardo R., et al.
Publicado: (2008)

AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer
por: Choudhury, Yashmin, et al.
Publicado: (2014)

The protective effects of maltol on cisplatin-induced nephrotoxicity through the AMPK-mediated PI3K/Akt and p53 signaling pathways
por: Mi, Xiao-jie, et al.
Publicado: (2018)

Proteome Analysis of USP7 Substrates Revealed Its Role in Melanoma Through PI3K/Akt/FOXO and AMPK Pathways
por: Gao, Lanyang, et al.
Publicado: (2021)

Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way
por: En, Qiao, et al.
Publicado: (2021)

Curcumin (CUMINUP60®) mitigates exercise fatigue through regulating PI3K/Akt/AMPK/mTOR pathway in mice
por: Hu, Minghui, et al.
Publicado: (2023)

Retraction: Central Exercise Action Increases the AMPK and mTOR Response to Leptin
Publicado: (2018)

Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis
por: Tan, Tan, et al.
Publicado: (2023)

Leptin Promotes HTR-8/SVneo Cell Invasion via the Crosstalk between MTA1/WNT and PI3K/AKT Pathways
por: Fan, Minghua, et al.
Publicado: (2022)

Corrigendum: Proteome Analysis of USP7 Substrates Revealed Its Role in Melanoma Through PI3K/Akt/FOXO and AMPK Pathways
por: Gao, Lanyang, et al.
Publicado: (2021)

Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis
por: Zhang, Eryun, et al.
Publicado: (2022)

Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling
por: Leung, A., et al.
Publicado: (2023)

Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation
por: Li, Tianxia, et al.
Publicado: (2020)

Metformin induces pyroptosis in leptin receptor-defective hepatocytes via overactivation of the AMPK axis
por: Liu, Bingli, et al.
Publicado: (2023)

Macrophage migration inhibitory factor promotes cardiac stem cell proliferation and endothelial differentiation through the activation of the PI3K/Akt/mTOR and AMPK pathways
por: CUI, JINJIN, et al.
Publicado: (2016)

Antidiabetic Effect of Tibetan Medicine Tang-Kang-Fu-San in db/db Mice via Activation of PI3K/Akt and AMPK Pathways
por: Duan, Bailu, et al.
Publicado: (2017)

Ophiopogonin-B targets PTP1B to inhibit the malignant progression of hepatocellular carcinoma by regulating the PI3K/AKT and AMPK signaling pathways
por: Yuan, Fang, et al.
Publicado: (2022)

Zhen-Wu-Tang Induced Mitophagy to Protect Mitochondrial Function in Chronic Glomerulonephritis via PI3K/AKT/mTOR and AMPK Pathways
por: Liu, Bihao, et al.
Publicado: (2021)

Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle
por: Roustit, Manon M, et al.
Publicado: (2014)

Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria
por: Hernández, Jessica Soto, et al.
Publicado: (2014)

Effects of Exercise on AMPK Signaling and Downstream Components to PI3K in Rat with Type 2 Diabetes
por: Cao, Shicheng, et al.
Publicado: (2012)

Metformin alleviates neurocognitive impairment in aging via activation of AMPK/BDNF/PI3K pathway
por: Ameen, Omnia, et al.
Publicado: (2022)

Quercetin ameliorates chicken quality by activating the PI3K/PKB/AMPK signaling pathway in broilers
por: Wang, Mi, et al.
Publicado: (2022)

Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
por: Duan, Fengsen, et al.
Publicado: (2020)

IQGAP1 binds AMPK and is required for maximum AMPK activation
por: Hedman, Andrew C., et al.
Publicado: (2020)

AMPK and Diseases: State of the Art Regulation by AMPK-Targeting Molecules
por: Tarasiuk, Olga, et al.
Publicado: (2022)

P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death
por: Bian, Shu, et al.
Publicado: (2013)

Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells
por: Chen, Ya-Hui, et al.
Publicado: (2021)

Targeting ACLY Attenuates Tumor Growth and Acquired Cisplatin Resistance in Ovarian Cancer by Inhibiting the PI3K–AKT Pathway and Activating the AMPK–ROS Pathway
por: Wei, Xuan, et al.
Publicado: (2021)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nqul8e836ha19u5ahg8auqu05r