Cargando…

Whole-Exome Sequencing in a South American Cohort Links ALDH1A3, FOXN1 and Retinoic Acid Regulation Pathways to Autism Spectrum Disorders

Autism spectrum disorders (ASDs) are a range of complex neurodevelopmental conditions principally characterized by dysfunctions linked to mental development. Previous studies have shown that there are more than 1000 genes likely involved in ASD, expressed mainly in brain and highly interconnected am...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moreno-Ramos, Oscar A., Olivares, Ana María, Haider, Neena B., de Autismo, Liga Colombiana, Lattig, María Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564166/ https://www.ncbi.nlm.nih.gov/pubmed/26352270 http://dx.doi.org/10.1371/journal.pone.0135927

Ejemplares similares

Linking ALDH1 and retinoic acid signaling
por: Markham, Nicholas O., et al.
Publicado: (2019)

FOXN1 in thymus organogenesis and development
por: Vaidya, Harsh Jayesh, et al.
Publicado: (2016)

Foxn1[Cre] Expression in the Male Germline
por: Shi, Jianjun, et al.
Publicado: (2016)

FOXN1 deficient nude severe combined immunodeficiency
por: Rota, Ioanna A., et al.
Publicado: (2017)

Foxn1 in Skin Development, Homeostasis and Wound Healing
por: Bukowska, Joanna, et al.
Publicado: (2018)

The role of 5-HTTLPR in autism spectrum disorder: New evidence and a meta-analysis of this polymorphism in Latin American population with psychiatric disorders
por: Nuñez-Rios, D. L., et al.
Publicado: (2020)

ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries
por: Bowles, Josephine, et al.
Publicado: (2016)

PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling
por: Verma, Mamta, et al.
Publicado: (2021)

Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary
por: Chassot, Anne-Amandine, et al.
Publicado: (2020)

An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts
por: Bredenkamp, Nicholas, et al.
Publicado: (2014)

FOXN1 Gene Considerations in Severe Combined Immunodeficiency Treatment in Children
por: Torres, Stephanie, et al.
Publicado: (2022)

Exome Evaluation of Autism-Associated Genes in Amazon American Populations
por: da Costa, Giovana E., et al.
Publicado: (2022)

A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
por: Li, Jianfeng, et al.
Publicado: (2021)

Insights on Foxn1 Biological Significance and Usages of the “Nude” Mouse in Studies of T-Lymphopoiesis
por: Zhang, Zhijie, et al.
Publicado: (2012)

FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program
por: Romano, Rosa, et al.
Publicado: (2013)

Recombinant FOXN1 fusion protein increases T cell generation in aged mice
por: Zhao, Jin, et al.
Publicado: (2023)

Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation
por: Reis, Maria Danielma dos Santos, et al.
Publicado: (2015)

ALDH1A1 Deficiency in Gorlin Syndrome Suggests a Central Role for Retinoic Acid and ATM Deficits in Radiation Carcinogenesis
por: Weber, Thomas J., et al.
Publicado: (2014)

ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression
por: Lavudi, Kousalya, et al.
Publicado: (2023)

Integrated analysis of whole-exome sequencing and transcriptome profiling in males with autism spectrum disorders
por: Codina-Solà, Marta, et al.
Publicado: (2015)

Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder
por: Hashimoto, Ryota, et al.
Publicado: (2016)

FOXN1(GFP/w) Reporter hESCs Enable Identification of Integrin-β4, HLA-DR, and EpCAM as Markers of Human PSC-Derived FOXN1(+) Thymic Epithelial Progenitors
por: Soh, Chew-Li, et al.
Publicado: (2014)

Meis1 regulates Foxn4 expression during retinal progenitor cell differentiation
por: Islam, Mohammed M., et al.
Publicado: (2013)

Comparative Hair Restorer Efficacy of Medicinal Herb on Nude (Foxn1(nu)) Mice
por: Begum, Shahnaz, et al.
Publicado: (2014)

Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells
por: Lv, Peng, et al.
Publicado: (2020)

Up-regulation of FOXN3-AS1 in invasive ductal carcinoma of breast cancer patients
por: Molaei Ramshe, Samira, et al.
Publicado: (2021)

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency
por: Rota, Ioanna A., et al.
Publicado: (2021)

Targeting S100A9–ALDH1A1–Retinoic Acid Signaling to Suppress Brain Relapse in EGFR-Mutant Lung Cancer
por: Biswas, Anup Kumar, et al.
Publicado: (2022)

Recent Advances in Autism Spectrum Disorders: Applications of Whole Exome Sequencing Technology
por: Sener, Elif Funda, et al.
Publicado: (2016)

Integration of Transcriptome and Exome Genotyping Identifies Significant Variants with Autism Spectrum Disorder
por: Almandil, Noor B., et al.
Publicado: (2022)

Consequences of Lineage-Specific Gene Loss on Functional Evolution of Surviving Paralogs: ALDH1A and Retinoic Acid Signaling in Vertebrate Genomes
por: Cañestro, Cristian, et al.
Publicado: (2009)

Retinoic acid homeostasis through aldh1a2 and cyp26a1 mediates meiotic entry in Nile tilapia (Oreochromis niloticus)
por: Feng, Ruijuan, et al.
Publicado: (2015)

The Retinoid-Related Orphan Receptor RORα Promotes Keratinocyte Differentiation via FOXN1
por: Dai, Jun, et al.
Publicado: (2013)

CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis
por: Huot, Geneviève, et al.
Publicado: (2014)

Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution
por: O’Neill, Kathy E., et al.
Publicado: (2016)

Foxn1-β5t transcriptional axis controls CD8(+) T-cell production in the thymus
por: Uddin, Muhammad Myn, et al.
Publicado: (2017)

FOXN3 hyperglycemic risk allele and insulin sensitivity in humans
por: Erickson, Melissa L, et al.
Publicado: (2019)

Molecular Evidence for a Thymus-Independent Partial T Cell Development in a FOXN1(−/−) Athymic Human Fetus
por: Fusco, Anna, et al.
Publicado: (2013)

Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency)
por: Mills, Philippa B., et al.
Publicado: (2010)

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations
por: O’Roak, Brian J., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_jrrqvab2nb452gst78lj8tt1j0