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Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma

Allergy is inversely related to glioma risk. To determine whether prediagnostic allergy-related serum proteins are associated with glioma, we conducted a nested case-control study of seven cytokines (IL4, IL13, IL5, IL6, IL10, IFNG, TGFB2), two soluble cytokine receptors (sIL4RA, sIL13RA2) and three...

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Autores principales: Schwartzbaum, Judith, Seweryn, Michal, Holloman, Christopher, Harris, Randall, Handelman, Samuel K., Rempala, Grzegorz A., Huang, Ruo-Pan, Burkholder, Brett, Brandemihl, Adam, Kallberg, Henrik, Johannesen, Tom Borge, Ahlbom, Anders, Feychting, Maria, Grimsrud, Tom K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564184/
https://www.ncbi.nlm.nih.gov/pubmed/26352148
http://dx.doi.org/10.1371/journal.pone.0137503
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author Schwartzbaum, Judith
Seweryn, Michal
Holloman, Christopher
Harris, Randall
Handelman, Samuel K.
Rempala, Grzegorz A.
Huang, Ruo-Pan
Burkholder, Brett
Brandemihl, Adam
Kallberg, Henrik
Johannesen, Tom Borge
Ahlbom, Anders
Feychting, Maria
Grimsrud, Tom K.
author_facet Schwartzbaum, Judith
Seweryn, Michal
Holloman, Christopher
Harris, Randall
Handelman, Samuel K.
Rempala, Grzegorz A.
Huang, Ruo-Pan
Burkholder, Brett
Brandemihl, Adam
Kallberg, Henrik
Johannesen, Tom Borge
Ahlbom, Anders
Feychting, Maria
Grimsrud, Tom K.
author_sort Schwartzbaum, Judith
collection PubMed
description Allergy is inversely related to glioma risk. To determine whether prediagnostic allergy-related serum proteins are associated with glioma, we conducted a nested case-control study of seven cytokines (IL4, IL13, IL5, IL6, IL10, IFNG, TGFB2), two soluble cytokine receptors (sIL4RA, sIL13RA2) and three allergy-related transcription factors (FOXP3, STAT3, STAT6) using serum specimens from the Janus Serum Bank Cohort in Oslo, Norway. Blood donors subsequently diagnosed with glioma (n = 487) were matched to controls (n = 487) on age and date of blood draw and sex. We first estimated individual effects of the 12 serum proteins and then interactions between IL4 and IL13 and their receptors using conditional logistic regression. We next tested equality of case-control inter-correlations among the 12 serum proteins. We found that TGFB2 is inversely related to glioblastoma (Odds Ratio (OR) = 0.87, 95% Confidence Interval (CI)) = 0.76, 0.98). In addition, ≤ 5 years before diagnosis, we observed associations between IL4 (OR = 0.82, 95% CI = 0.66, 1.01), sIL4RA (OR = 0.80, 95% CI = 0.65, 1.00), their interaction (OR = 1.06, 95% CI = 1.01, 1.12) and glioblastoma. This interaction was apparent > 20 years before diagnosis (IL4-sIL4RA OR = 1.20, 95% CI = 1.05, 1.37). Findings for glioma were similar. Case correlations were different from control correlations stratified on time before diagnosis. Five years or less before diagnosis, correlations among case serum proteins were weaker than were those among controls. Our findings suggest that IL4 and sIL4RA reduce glioma risk long before diagnosis and early gliomagenesis affects circulating immune function proteins.
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spelling pubmed-45641842015-09-17 Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma Schwartzbaum, Judith Seweryn, Michal Holloman, Christopher Harris, Randall Handelman, Samuel K. Rempala, Grzegorz A. Huang, Ruo-Pan Burkholder, Brett Brandemihl, Adam Kallberg, Henrik Johannesen, Tom Borge Ahlbom, Anders Feychting, Maria Grimsrud, Tom K. PLoS One Research Article Allergy is inversely related to glioma risk. To determine whether prediagnostic allergy-related serum proteins are associated with glioma, we conducted a nested case-control study of seven cytokines (IL4, IL13, IL5, IL6, IL10, IFNG, TGFB2), two soluble cytokine receptors (sIL4RA, sIL13RA2) and three allergy-related transcription factors (FOXP3, STAT3, STAT6) using serum specimens from the Janus Serum Bank Cohort in Oslo, Norway. Blood donors subsequently diagnosed with glioma (n = 487) were matched to controls (n = 487) on age and date of blood draw and sex. We first estimated individual effects of the 12 serum proteins and then interactions between IL4 and IL13 and their receptors using conditional logistic regression. We next tested equality of case-control inter-correlations among the 12 serum proteins. We found that TGFB2 is inversely related to glioblastoma (Odds Ratio (OR) = 0.87, 95% Confidence Interval (CI)) = 0.76, 0.98). In addition, ≤ 5 years before diagnosis, we observed associations between IL4 (OR = 0.82, 95% CI = 0.66, 1.01), sIL4RA (OR = 0.80, 95% CI = 0.65, 1.00), their interaction (OR = 1.06, 95% CI = 1.01, 1.12) and glioblastoma. This interaction was apparent > 20 years before diagnosis (IL4-sIL4RA OR = 1.20, 95% CI = 1.05, 1.37). Findings for glioma were similar. Case correlations were different from control correlations stratified on time before diagnosis. Five years or less before diagnosis, correlations among case serum proteins were weaker than were those among controls. Our findings suggest that IL4 and sIL4RA reduce glioma risk long before diagnosis and early gliomagenesis affects circulating immune function proteins. Public Library of Science 2015-09-09 /pmc/articles/PMC4564184/ /pubmed/26352148 http://dx.doi.org/10.1371/journal.pone.0137503 Text en © 2015 Schwartzbaum et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Schwartzbaum, Judith
Seweryn, Michal
Holloman, Christopher
Harris, Randall
Handelman, Samuel K.
Rempala, Grzegorz A.
Huang, Ruo-Pan
Burkholder, Brett
Brandemihl, Adam
Kallberg, Henrik
Johannesen, Tom Borge
Ahlbom, Anders
Feychting, Maria
Grimsrud, Tom K.
Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma
title Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma
title_full Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma
title_fullStr Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma
title_full_unstemmed Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma
title_short Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma
title_sort association between prediagnostic allergy-related serum cytokines and glioma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564184/
https://www.ncbi.nlm.nih.gov/pubmed/26352148
http://dx.doi.org/10.1371/journal.pone.0137503
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