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Use of Genome Engineering to Create Patient Specific MLL Translocations in Primary Human Hematopoietic Stem and Progenitor Cells

One of the challenging questions in cancer biology is how a normal cell transforms into a cancer cell. There is strong evidence that specific chromosomal translocations are a key element in this transformation process. Our studies focus on understanding the developmental mechanism by which a normal...

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Detalles Bibliográficos
Autores principales:	Breese, Erin H., Buechele, Corina, Dawson, Catherine, Cleary, Michael L., Porteus, Matthew H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564237/ https://www.ncbi.nlm.nih.gov/pubmed/26351841 http://dx.doi.org/10.1371/journal.pone.0136644

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