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Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

The class Ic antiarrhythmic drug flecainide inhibits KCNH2-encoded “hERG” potassium channels at clinically relevant concentrations. The aim of this study was to elucidate the underlying molecular basis of this action. Patch clamp recordings of hERG current (I(hERG)) were made from hERG expressing ce...

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Detalles Bibliográficos
Autores principales:	Melgari, Dario, Zhang, Yihong, El Harchi, Aziza, Dempsey, Christopher E., Hancox, Jules C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Academic Press 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564290/ https://www.ncbi.nlm.nih.gov/pubmed/26159617 http://dx.doi.org/10.1016/j.yjmcc.2015.06.021

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