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Valproic Acid-Induced Severe Acute Pancreatitis with Pseudocyst Formation: Report of a Case

Valproic acid is the most widely used anti-epilep­tic drug in children, and it is probably the most frequent cause of drug-induced acute pancreatitis. Outcomes for patients with valproic acid-associated pancreatitis vary from full recovery after discontinuation of the drug to severe acute pancreatit...

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Autores principales: Ray, Sukanta, Khamrui, Sujan, Kataria, Mohnish, Biswas, Jayanta, Saha, Suman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564375/
https://www.ncbi.nlm.nih.gov/pubmed/26366333
http://dx.doi.org/10.7759/cureus.297
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author Ray, Sukanta
Khamrui, Sujan
Kataria, Mohnish
Biswas, Jayanta
Saha, Suman
author_facet Ray, Sukanta
Khamrui, Sujan
Kataria, Mohnish
Biswas, Jayanta
Saha, Suman
author_sort Ray, Sukanta
collection PubMed
description Valproic acid is the most widely used anti-epilep­tic drug in children, and it is probably the most frequent cause of drug-induced acute pancreatitis. Outcomes for patients with valproic acid-associated pancreatitis vary from full recovery after discontinuation of the drug to severe acute pancreatitis and death. Here, we present a case of valproic acid-induced severe acute pancreatitis with pseudocyst formation in a 10-year-old girl with cerebral palsy and generalized tonic-clonic seizure. There was no resolution of the pseudocyst after discontinuation of valproic acid. The patient became symptomatic with a progressive increase in the size of the pseudocyst. She was successfully treated with cystogastrostomy and was well at 12-month follow-up.
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spelling pubmed-45643752015-09-11 Valproic Acid-Induced Severe Acute Pancreatitis with Pseudocyst Formation: Report of a Case Ray, Sukanta Khamrui, Sujan Kataria, Mohnish Biswas, Jayanta Saha, Suman Cureus General Surgery Valproic acid is the most widely used anti-epilep­tic drug in children, and it is probably the most frequent cause of drug-induced acute pancreatitis. Outcomes for patients with valproic acid-associated pancreatitis vary from full recovery after discontinuation of the drug to severe acute pancreatitis and death. Here, we present a case of valproic acid-induced severe acute pancreatitis with pseudocyst formation in a 10-year-old girl with cerebral palsy and generalized tonic-clonic seizure. There was no resolution of the pseudocyst after discontinuation of valproic acid. The patient became symptomatic with a progressive increase in the size of the pseudocyst. She was successfully treated with cystogastrostomy and was well at 12-month follow-up. Cureus 2015-08-08 /pmc/articles/PMC4564375/ /pubmed/26366333 http://dx.doi.org/10.7759/cureus.297 Text en Copyright © 2015, Ray et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle General Surgery
Ray, Sukanta
Khamrui, Sujan
Kataria, Mohnish
Biswas, Jayanta
Saha, Suman
Valproic Acid-Induced Severe Acute Pancreatitis with Pseudocyst Formation: Report of a Case
title Valproic Acid-Induced Severe Acute Pancreatitis with Pseudocyst Formation: Report of a Case
title_full Valproic Acid-Induced Severe Acute Pancreatitis with Pseudocyst Formation: Report of a Case
title_fullStr Valproic Acid-Induced Severe Acute Pancreatitis with Pseudocyst Formation: Report of a Case
title_full_unstemmed Valproic Acid-Induced Severe Acute Pancreatitis with Pseudocyst Formation: Report of a Case
title_short Valproic Acid-Induced Severe Acute Pancreatitis with Pseudocyst Formation: Report of a Case
title_sort valproic acid-induced severe acute pancreatitis with pseudocyst formation: report of a case
topic General Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564375/
https://www.ncbi.nlm.nih.gov/pubmed/26366333
http://dx.doi.org/10.7759/cureus.297
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