Atorvastatin and sildenafil decrease vascular TGF-β levels and MMP-2 activity and ameliorate arterial remodeling in a model of renovascular hypertension

Imbalanced matrix metalloproteinase (MMP)-2 activity and transforming growth factor expression (TGF-β) are involved in vascular remodeling of hypertension. Atorvastatin and sildenafil exert antioxidant and pleiotropic effects that may result in cardiovascular protection. We hypothesized that atorvas...

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Detalles Bibliográficos
Autores principales: Guimarães, Danielle A., Rizzi, Elen, Ceron, Carla S., Martins-Oliveira, Alisson, Gerlach, Raquel F., Shiva, Sruti, Tanus-Santos, Jose E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564390/
https://www.ncbi.nlm.nih.gov/pubmed/26343345
http://dx.doi.org/10.1016/j.redox.2015.08.017

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