Cargando…
Neural networks underlying implicit and explicit moral evaluations in psychopathy
Psychopathy, characterized by symptoms of emotional detachment, reduced guilt and empathy and a callous disregard for the rights and welfare of others, is a strong risk factor for immoral behavior. Psychopathy is also marked by abnormal attention with downstream consequences on emotional processing....
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564570/ https://www.ncbi.nlm.nih.gov/pubmed/26305476 http://dx.doi.org/10.1038/tp.2015.117 |
_version_ | 1782389453728251904 |
---|---|
author | Yoder, K J Harenski, C Kiehl, K A Decety, J |
author_facet | Yoder, K J Harenski, C Kiehl, K A Decety, J |
author_sort | Yoder, K J |
collection | PubMed |
description | Psychopathy, characterized by symptoms of emotional detachment, reduced guilt and empathy and a callous disregard for the rights and welfare of others, is a strong risk factor for immoral behavior. Psychopathy is also marked by abnormal attention with downstream consequences on emotional processing. To examine the influence of task demands on moral evaluation in psychopathy, functional magnetic resonance imaging was used to measure neural response and functional connectivity in 88 incarcerated male subjects (28 with Psychopathy Checklist Revised (PCL-R) scores ⩾30) while they viewed dynamic visual stimuli depicting interpersonal harm and interpersonal assistance in two contexts, implicit and explicit. During the implicit task, high psychopathy was associated with reduced activity in the dorsolateral prefrontal cortex and caudate when viewing harmful compared with helpful social interactions. Functional connectivity seeded in the right amygdala and right temporoparietal junction revealed decreased coupling with the anterior cingulate cortex (ACC), anterior insula, striatum and ventromedial prefrontal cortex. In the explicit task, higher trait psychopathy predicted reduced signal change in ACC and amygdala, accompanied by decreased functional connectivity to temporal pole, insula and striatum, but increased connectivity with dorsal ACC. Psychopathy did not influence behavioral performance in either task, despite differences in neural activity and functional connectivity. These findings provide the first direct evidence that hemodynamic activity and neural coupling within the salience network are disrupted in psychopathy, and that the effects of psychopathy on moral evaluation are influenced by attentional demands. |
format | Online Article Text |
id | pubmed-4564570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45645702015-09-18 Neural networks underlying implicit and explicit moral evaluations in psychopathy Yoder, K J Harenski, C Kiehl, K A Decety, J Transl Psychiatry Original Article Psychopathy, characterized by symptoms of emotional detachment, reduced guilt and empathy and a callous disregard for the rights and welfare of others, is a strong risk factor for immoral behavior. Psychopathy is also marked by abnormal attention with downstream consequences on emotional processing. To examine the influence of task demands on moral evaluation in psychopathy, functional magnetic resonance imaging was used to measure neural response and functional connectivity in 88 incarcerated male subjects (28 with Psychopathy Checklist Revised (PCL-R) scores ⩾30) while they viewed dynamic visual stimuli depicting interpersonal harm and interpersonal assistance in two contexts, implicit and explicit. During the implicit task, high psychopathy was associated with reduced activity in the dorsolateral prefrontal cortex and caudate when viewing harmful compared with helpful social interactions. Functional connectivity seeded in the right amygdala and right temporoparietal junction revealed decreased coupling with the anterior cingulate cortex (ACC), anterior insula, striatum and ventromedial prefrontal cortex. In the explicit task, higher trait psychopathy predicted reduced signal change in ACC and amygdala, accompanied by decreased functional connectivity to temporal pole, insula and striatum, but increased connectivity with dorsal ACC. Psychopathy did not influence behavioral performance in either task, despite differences in neural activity and functional connectivity. These findings provide the first direct evidence that hemodynamic activity and neural coupling within the salience network are disrupted in psychopathy, and that the effects of psychopathy on moral evaluation are influenced by attentional demands. Nature Publishing Group 2015-08 2015-08-25 /pmc/articles/PMC4564570/ /pubmed/26305476 http://dx.doi.org/10.1038/tp.2015.117 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Original Article Yoder, K J Harenski, C Kiehl, K A Decety, J Neural networks underlying implicit and explicit moral evaluations in psychopathy |
title | Neural networks underlying implicit and explicit moral evaluations in psychopathy |
title_full | Neural networks underlying implicit and explicit moral evaluations in psychopathy |
title_fullStr | Neural networks underlying implicit and explicit moral evaluations in psychopathy |
title_full_unstemmed | Neural networks underlying implicit and explicit moral evaluations in psychopathy |
title_short | Neural networks underlying implicit and explicit moral evaluations in psychopathy |
title_sort | neural networks underlying implicit and explicit moral evaluations in psychopathy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564570/ https://www.ncbi.nlm.nih.gov/pubmed/26305476 http://dx.doi.org/10.1038/tp.2015.117 |
work_keys_str_mv | AT yoderkj neuralnetworksunderlyingimplicitandexplicitmoralevaluationsinpsychopathy AT harenskic neuralnetworksunderlyingimplicitandexplicitmoralevaluationsinpsychopathy AT kiehlka neuralnetworksunderlyingimplicitandexplicitmoralevaluationsinpsychopathy AT decetyj neuralnetworksunderlyingimplicitandexplicitmoralevaluationsinpsychopathy |