A Tale from TGF-β Superfamily for Thymus Ontogeny and Function

Multiple signaling pathways control every aspect of cell behavior, organ formation, and tissue homeostasis throughout the lifespan of any individual. This review takes an ontogenetic view focused on the large superfamily of TGF-β/bone morphogenetic protein ligands to address thymus morphogenesis and...

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Detalles Bibliográficos
Autores principales: Jurberg, Arnon Dias, Vasconcelos-Fontes, Larissa, Cotta-de-Almeida, Vinícius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564722/
https://www.ncbi.nlm.nih.gov/pubmed/26441956
http://dx.doi.org/10.3389/fimmu.2015.00442
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author Jurberg, Arnon Dias
Vasconcelos-Fontes, Larissa
Cotta-de-Almeida, Vinícius
author_facet Jurberg, Arnon Dias
Vasconcelos-Fontes, Larissa
Cotta-de-Almeida, Vinícius
author_sort Jurberg, Arnon Dias
collection PubMed
description Multiple signaling pathways control every aspect of cell behavior, organ formation, and tissue homeostasis throughout the lifespan of any individual. This review takes an ontogenetic view focused on the large superfamily of TGF-β/bone morphogenetic protein ligands to address thymus morphogenesis and function in T cell differentiation. Recent findings on a role of GDF11 for reversing aging-related phenotypes are also discussed.
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spelling pubmed-45647222015-10-05 A Tale from TGF-β Superfamily for Thymus Ontogeny and Function Jurberg, Arnon Dias Vasconcelos-Fontes, Larissa Cotta-de-Almeida, Vinícius Front Immunol Immunology Multiple signaling pathways control every aspect of cell behavior, organ formation, and tissue homeostasis throughout the lifespan of any individual. This review takes an ontogenetic view focused on the large superfamily of TGF-β/bone morphogenetic protein ligands to address thymus morphogenesis and function in T cell differentiation. Recent findings on a role of GDF11 for reversing aging-related phenotypes are also discussed. Frontiers Media S.A. 2015-09-10 /pmc/articles/PMC4564722/ /pubmed/26441956 http://dx.doi.org/10.3389/fimmu.2015.00442 Text en Copyright © 2015 Jurberg, Vasconcelos-Fontes and Cotta-de-Almeida. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Jurberg, Arnon Dias
Vasconcelos-Fontes, Larissa
Cotta-de-Almeida, Vinícius
A Tale from TGF-β Superfamily for Thymus Ontogeny and Function
title A Tale from TGF-β Superfamily for Thymus Ontogeny and Function
title_full A Tale from TGF-β Superfamily for Thymus Ontogeny and Function
title_fullStr A Tale from TGF-β Superfamily for Thymus Ontogeny and Function
title_full_unstemmed A Tale from TGF-β Superfamily for Thymus Ontogeny and Function
title_short A Tale from TGF-β Superfamily for Thymus Ontogeny and Function
title_sort tale from tgf-β superfamily for thymus ontogeny and function
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564722/
https://www.ncbi.nlm.nih.gov/pubmed/26441956
http://dx.doi.org/10.3389/fimmu.2015.00442
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