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Facile Discovery of a Diverse Panel of Anti-Ebola Virus Antibodies by Immune Repertoire Mining

The ongoing evolution of Ebolaviruses poses significant challenges to the development of immunodiagnostics for detecting emergent viral variants. There is a critical need for the discovery of monoclonal antibodies with distinct affinities and specificities for different Ebolaviruses. We developed an...

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Detalles Bibliográficos
Autores principales: Wang, Bo, Kluwe, Christien A., Lungu, Oana I., DeKosky, Brandon J., Kerr, Scott A., Johnson, Erik L., Jung, Jiwon, Rezigh, Alec B., Carroll, Sean M., Reyes, Ann N., Bentz, Janelle R., Villanueva, Itamar, Altman, Amy L., Davey, Robert A., Ellington, Andrew D., Georgiou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564727/
https://www.ncbi.nlm.nih.gov/pubmed/26355042
http://dx.doi.org/10.1038/srep13926