Cargando…

EGFR Exon 18 Mutations in East Asian Patients with Lung Adenocarcinomas: A Comprehensive Investigation of Prevalence, Clinicopathologic Characteristics and Prognosis

Our aim was to investigate the clinical and pathologic characteristics of the epidermal growth factor receptor (EGFR) exon 18 mutations in East Asian lung adenocarcinomas patients. A total of 1,201 lung adenocarcinomas were analyzed for mutation in EGFR. Clinical and pathologic characteristics of pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Chao, Wang, Rui, Li, Yuan, Pan, Yunjian, Zhang, Yang, Li, Hang, Zheng, Difan, Zheng, Shanbo, Shen, Xuxia, Sun, Yihua, Chen, Haiquan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564802/ https://www.ncbi.nlm.nih.gov/pubmed/26354324 http://dx.doi.org/10.1038/srep13959

Ejemplares similares

Former smokers with non‐small‐cell lung cancers: a comprehensive investigation of clinicopathologic characteristics, oncogenic drivers, and prognosis
por: Zheng, Shanbo, et al.
Publicado: (2016)

The prevalence and prognostic significance of KRAS mutation subtypes in lung adenocarcinomas from Chinese populations
por: Zheng, Difan, et al.
Publicado: (2016)

Minor Components of Micropapillary and Solid Subtypes in Lung Adenocarcinoma are Predictors of Lymph Node Metastasis and Poor Prognosis
por: Zhao, Yue, et al.
Publicado: (2016)

SOX2 expression is associated with FGFR fusion genes and predicts favorable outcome in lung squamous cell carcinomas
por: Zheng, Shanbo, et al.
Publicado: (2015)

Clinical Significance of Complex Glandular Patterns in Lung Adenocarcinoma: Clinicopathologic and Molecular Study in a Large Series of Cases
por: Kuang, Muyu, et al.
Publicado: (2018)

MET exon 14 skipping defines a unique molecular class of non-small cell lung cancer
por: Zheng, Difan, et al.
Publicado: (2016)

ALK-Rearranged Lung Cancer in Chinese: A Comprehensive Assessment of Clinicopathology, IHC, FISH and RT-PCR
por: Li, Yuan, et al.
Publicado: (2013)

Thymoma and thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic analysis of 18 cases
por: Shen, Xuxia, et al.
Publicado: (2018)

Clinical and genetic features of lung squamous cell cancer in never-smokers
por: Huang, Yangle, et al.
Publicado: (2016)

Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers
por: Li, Chenguang, et al.
Publicado: (2011)

Analysis of mutational and clinicopathologic characteristics of lung adenocarcinoma with clear cell component
por: Gu, Chang, et al.
Publicado: (2016)

Clinicopathologic and molecular characteristics of Chinese lung adenocarcinoma patients with EGFR exon 20 insertion mutations
por: Wang, Lifeng, et al.
Publicado: (2022)

ALK-rearrangement neuroendocrine carcinoma of the lung: a comprehensive study of a rare case series and review of literature
por: Zheng, Qiang, et al.
Publicado: (2018)

PIK3CA Mutations Frequently Coexist with EGFR/KRAS Mutations in Non-Small Cell Lung Cancer and Suggest Poor Prognosis in EGFR/KRAS Wildtype Subgroup
por: Wang, Lei, et al.
Publicado: (2014)

Impact of Concurrent Genomic Alterations Detected by Comprehensive Genomic Sequencing on Clinical Outcomes in East-Asian Patients with EGFR-Mutated Lung Adenocarcinoma
por: Sato, Seijiro, et al.
Publicado: (2018)

The non-small cell lung cancer EGFR extracellular domain mutation, M277E, is oncogenic and drug-sensitive
por: Yu, Su, et al.
Publicado: (2017)

Increased Tumor Intrinsic Growth Potential and Decreased Immune Function Orchestrate the Progression of Lung Adenocarcinoma
por: Zhao, Yue, et al.
Publicado: (2022)

MicroRNA Signature of Lung Adenocarcinoma with EGFR Exon 19 Deletion
por: Ju, Lixia, et al.
Publicado: (2017)

Erlotinib versus gefitinib for brain metastases in Asian patients with exon 19 EGFR-mutant lung adenocarcinoma: a retrospective, multicenter study
por: Jiang, Ye, et al.
Publicado: (2018)

Development and external validation of a composite immune-clinical prognostic model associated with EGFR mutation in East-Asian patients with lung adenocarcinoma
por: Liu, Chengming, et al.
Publicado: (2021)

Clinical outcomes of EGFR-TKI treatment and genetic heterogeneity in lung adenocarcinoma patients with EGFR mutations on exons 19 and 21
por: Yu, Jiang-Yong, et al.
Publicado: (2016)

Differential clinicopathological features, treatments and outcomes in patients with Exon 19 deletion and Exon 21 L858R EGFR mutation-positive adenocarcinoma non-small-cell lung cancer
por: Batra, Ullas, et al.
Publicado: (2023)

Genomic and immune profiling of pre-invasive lung adenocarcinoma
por: Chen, Haiquan, et al.
Publicado: (2019)

Comparison of clinical features, molecular alterations, and prognosis in morphological subgroups of lung invasive mucinous adenocarcinoma
por: Cai, Deng, et al.
Publicado: (2014)

Osimertinib as treatment for EGFR exon 20 insertion-positive lung adenocarcinoma
por: Murano, Chihiro, et al.
Publicado: (2019)

Missense Mutations in Exons 18–24 of EGFR in Hepatocellular Carcinoma Tissues
por: Panvichian, Ravat, et al.
Publicado: (2015)

Primary concomitant EGFR T790M mutation predicted worse prognosis in non-small cell lung cancer patients
por: Li, Hang, et al.
Publicado: (2014)

Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma
por: Zhang, Yang, et al.
Publicado: (2014)

The clinicopathological and molecular characteristics of resected EGFR‐mutant lung adenocarcinoma
por: Zhou, Wensheng, et al.
Publicado: (2022)

Score for lung adenocarcinoma in China with EGFR mutation of exon 19: Combination of clinical and radiological characteristics analysis
por: Shi, Zhang, et al.
Publicado: (2018)

Analyzing EGFR mutations and their association with clinicopathological characteristics and prognosis of patients with lung adenocarcinoma
por: Zhou, Xiuzhi, et al.
Publicado: (2018)

The prognostic and predictive value of solid subtype in invasive lung adenocarcinoma
por: Zhang, Yang, et al.
Publicado: (2014)

The first comprehensive database of germline pathogenic variants in East Asian cancer patients
por: Shi, Xiaoshun, et al.
Publicado: (2021)

Successful sequential tyrosine kinase inhibitors to overcome a rare compound of EGFR exon 18–18 and EGFR amplification: A case report
por: Wang, Pascal, et al.
Publicado: (2022)

Genetic Associations of Visfatin Polymorphisms with EGFR Status and Clinicopathologic Characteristics in Lung Adenocarcinoma
por: Chang, Sunny Li-Yun, et al.
Publicado: (2022)

Association of the programmed death ligand‐1 combined positive score in tumors and clinicopathological features in esophageal cancer
por: Huang, Ziling, et al.
Publicado: (2021)

Risk stratification model for patients with stage I invasive lung adenocarcinoma based on clinical and pathological predictors
por: Wang, Yiyang, et al.
Publicado: (2021)

Unusual metachronous lung adenocarcinomas harboring EGFR L858R/T790M mutations: A case report
por: Pei, Guotian, et al.
Publicado: (2020)

Comprehensive investigation of oncogenic driver mutations in Chinese non-small cell lung cancer patients
por: Wang, Rui, et al.
Publicado: (2015)

Identification of a large intra-exonic deletion in BRCA2 exon 18 in a pancreatic ductal adenocarcinoma
por: Debbabi, Inès, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ds6qil88shat9g0lm89ocbok2i