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The characteristics of HIV and AIDS patients with deep vein thrombosis at Dr. George Mukhari Academic Hospital

BACKGROUND: Deep vein thrombosis (DVT) is 10 times more prevalent in HIV and AIDS patients than in the general population and is more common in patients with severe immune suppression (CD4 < 200 cells/mL). Opportunistic infections render HIV and AIDS patients susceptible to a hypercoaguable state...

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Autores principales: Govender, Indiran, Mabuza, Honey L., Ogunbanjo, Gboyega A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS OpenJournals 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564893/
https://www.ncbi.nlm.nih.gov/pubmed/26245588
http://dx.doi.org/10.4102/phcfm.v7i1.690
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author Govender, Indiran
Mabuza, Honey L.
Ogunbanjo, Gboyega A.
author_facet Govender, Indiran
Mabuza, Honey L.
Ogunbanjo, Gboyega A.
author_sort Govender, Indiran
collection PubMed
description BACKGROUND: Deep vein thrombosis (DVT) is 10 times more prevalent in HIV and AIDS patients than in the general population and is more common in patients with severe immune suppression (CD4 < 200 cells/mL). Opportunistic infections render HIV and AIDS patients susceptible to a hypercoaguable state, including lower protein S levels. AIM AND SETTING: To present the profile of HIV and AIDS patients who developed DVT in the primary care wards of Dr. George Mukhari Academic Hospital (DGMAH), Garankuwa. METHODS: Cross-sectional study of clinical records of admitted HIV and AIDS patients without DVT to the primary care wards, DGMAH, from 01 February 2010 to 31 January 2011. RESULTS: Two hundred and twenty-nine patients were admitted and 17 (7.4%) developed DVT. Of those that developed DVT, eight (47%) had infection with tuberculosis (TB), four (24%) had pneumonia and four (24%) had gastroenteritis. The risk of developing DVT was 8/94 (8.5%) in those with TB, 4/53 (7.5%) in those with gastroenteritis and 4/75 (5.3%) in those with pneumonia. The mean duration of stay was 14.1 days in those with DVT versus 4.0 days in those without. CONCLUSION: HIV (and AIDS) is a hypercoaguable state and the risk of DVT is relatively high in patients with opportunistic infections. HIV and AIDS patients who are admitted to hospital with opportunistic infections may benefit from anti-thrombotic prophylaxis and further studies are needed to evaluate this.
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spelling pubmed-45648932016-02-03 The characteristics of HIV and AIDS patients with deep vein thrombosis at Dr. George Mukhari Academic Hospital Govender, Indiran Mabuza, Honey L. Ogunbanjo, Gboyega A. Afr J Prim Health Care Fam Med Scientific Letters BACKGROUND: Deep vein thrombosis (DVT) is 10 times more prevalent in HIV and AIDS patients than in the general population and is more common in patients with severe immune suppression (CD4 < 200 cells/mL). Opportunistic infections render HIV and AIDS patients susceptible to a hypercoaguable state, including lower protein S levels. AIM AND SETTING: To present the profile of HIV and AIDS patients who developed DVT in the primary care wards of Dr. George Mukhari Academic Hospital (DGMAH), Garankuwa. METHODS: Cross-sectional study of clinical records of admitted HIV and AIDS patients without DVT to the primary care wards, DGMAH, from 01 February 2010 to 31 January 2011. RESULTS: Two hundred and twenty-nine patients were admitted and 17 (7.4%) developed DVT. Of those that developed DVT, eight (47%) had infection with tuberculosis (TB), four (24%) had pneumonia and four (24%) had gastroenteritis. The risk of developing DVT was 8/94 (8.5%) in those with TB, 4/53 (7.5%) in those with gastroenteritis and 4/75 (5.3%) in those with pneumonia. The mean duration of stay was 14.1 days in those with DVT versus 4.0 days in those without. CONCLUSION: HIV (and AIDS) is a hypercoaguable state and the risk of DVT is relatively high in patients with opportunistic infections. HIV and AIDS patients who are admitted to hospital with opportunistic infections may benefit from anti-thrombotic prophylaxis and further studies are needed to evaluate this. AOSIS OpenJournals 2015-03-27 /pmc/articles/PMC4564893/ /pubmed/26245588 http://dx.doi.org/10.4102/phcfm.v7i1.690 Text en © 2015. The Authors http://creativecommons.org/licenses/by/2.0/ AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License.
spellingShingle Scientific Letters
Govender, Indiran
Mabuza, Honey L.
Ogunbanjo, Gboyega A.
The characteristics of HIV and AIDS patients with deep vein thrombosis at Dr. George Mukhari Academic Hospital
title The characteristics of HIV and AIDS patients with deep vein thrombosis at Dr. George Mukhari Academic Hospital
title_full The characteristics of HIV and AIDS patients with deep vein thrombosis at Dr. George Mukhari Academic Hospital
title_fullStr The characteristics of HIV and AIDS patients with deep vein thrombosis at Dr. George Mukhari Academic Hospital
title_full_unstemmed The characteristics of HIV and AIDS patients with deep vein thrombosis at Dr. George Mukhari Academic Hospital
title_short The characteristics of HIV and AIDS patients with deep vein thrombosis at Dr. George Mukhari Academic Hospital
title_sort characteristics of hiv and aids patients with deep vein thrombosis at dr. george mukhari academic hospital
topic Scientific Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564893/
https://www.ncbi.nlm.nih.gov/pubmed/26245588
http://dx.doi.org/10.4102/phcfm.v7i1.690
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