Cargando…

Spatial Analysis of Neonatal Congenital Hypothyroidism and Nitrate as an Environmental Pollutant in Isfahan Province During 2010-2013

BACKGROUND: Thyroid absorption of iodine could be encumbered by nitrate drinking water when it is transported to the fetal thyroid gland. Therefore, nitrate potentially causes congenital hypothyroidism (CH) due to thyroid dysfunction. In this study, we have not only aimed at spatial determination of...

Descripción completa

Detalles Bibliográficos
Autores principales: Mehrnejat, Neda, Yazdanpanah, Hojatollah, Fadaei Nobari, Reza, Hashemipour, Mahin, Maracy, Mohammadreza, Moafi, Mohammad, Mousavian, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564903/
https://www.ncbi.nlm.nih.gov/pubmed/26425331
http://dx.doi.org/10.4103/2008-7802.162952
_version_ 1782389516701532160
author Mehrnejat, Neda
Yazdanpanah, Hojatollah
Fadaei Nobari, Reza
Hashemipour, Mahin
Maracy, Mohammadreza
Moafi, Mohammad
Mousavian, Zahra
author_facet Mehrnejat, Neda
Yazdanpanah, Hojatollah
Fadaei Nobari, Reza
Hashemipour, Mahin
Maracy, Mohammadreza
Moafi, Mohammad
Mousavian, Zahra
author_sort Mehrnejat, Neda
collection PubMed
description BACKGROUND: Thyroid absorption of iodine could be encumbered by nitrate drinking water when it is transported to the fetal thyroid gland. Therefore, nitrate potentially causes congenital hypothyroidism (CH) due to thyroid dysfunction. In this study, we have not only aimed at spatial determination of CH distribution and nitrate concentration (NC) existing in drinking water, but also we intended to evaluate the probable impact of nitrate on CH incidence. METHODS: Annual average of nitrate in drinking-water as well as number of CH infants diagnosed through the screening program were applied to determine the incidence ratio of the disease for each town (from 2010 to 2013). Afterward, Arc GIS 9.3 was used to draw choropleth maps with quantile classification. Data were entered into SPSS 16.0 and Excel 2010 software. Finally, linear regression was applied for data analysis. RESULTS: The incidence rate of CH (considering transient and permanent cases) was about one in every 413 births. Khansar, Golpaygan, Naein, and Ardestan had the highest incidence rate of CH respectively. On the other hand, Tiran, Dehaghan, Khansar, and Fereydan had the highest level of nitrate drinking water. There was a strong relationship between the NC and incidence of CH in Khansar; however, this relationship was not significant (P = 0.392) in Isfahan province. CONCLUSIONS: Since there was not a significant relationship between NC in drinking-water and incidence of CH through linear regression analysis, more studies should be implemented to confirm or refute our observations.
format Online
Article
Text
id pubmed-4564903
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-45649032015-09-30 Spatial Analysis of Neonatal Congenital Hypothyroidism and Nitrate as an Environmental Pollutant in Isfahan Province During 2010-2013 Mehrnejat, Neda Yazdanpanah, Hojatollah Fadaei Nobari, Reza Hashemipour, Mahin Maracy, Mohammadreza Moafi, Mohammad Mousavian, Zahra Int J Prev Med Original Article BACKGROUND: Thyroid absorption of iodine could be encumbered by nitrate drinking water when it is transported to the fetal thyroid gland. Therefore, nitrate potentially causes congenital hypothyroidism (CH) due to thyroid dysfunction. In this study, we have not only aimed at spatial determination of CH distribution and nitrate concentration (NC) existing in drinking water, but also we intended to evaluate the probable impact of nitrate on CH incidence. METHODS: Annual average of nitrate in drinking-water as well as number of CH infants diagnosed through the screening program were applied to determine the incidence ratio of the disease for each town (from 2010 to 2013). Afterward, Arc GIS 9.3 was used to draw choropleth maps with quantile classification. Data were entered into SPSS 16.0 and Excel 2010 software. Finally, linear regression was applied for data analysis. RESULTS: The incidence rate of CH (considering transient and permanent cases) was about one in every 413 births. Khansar, Golpaygan, Naein, and Ardestan had the highest incidence rate of CH respectively. On the other hand, Tiran, Dehaghan, Khansar, and Fereydan had the highest level of nitrate drinking water. There was a strong relationship between the NC and incidence of CH in Khansar; however, this relationship was not significant (P = 0.392) in Isfahan province. CONCLUSIONS: Since there was not a significant relationship between NC in drinking-water and incidence of CH through linear regression analysis, more studies should be implemented to confirm or refute our observations. Medknow Publications & Media Pvt Ltd 2015-08-14 /pmc/articles/PMC4564903/ /pubmed/26425331 http://dx.doi.org/10.4103/2008-7802.162952 Text en Copyright: © 2015 Mehrnejat N. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Mehrnejat, Neda
Yazdanpanah, Hojatollah
Fadaei Nobari, Reza
Hashemipour, Mahin
Maracy, Mohammadreza
Moafi, Mohammad
Mousavian, Zahra
Spatial Analysis of Neonatal Congenital Hypothyroidism and Nitrate as an Environmental Pollutant in Isfahan Province During 2010-2013
title Spatial Analysis of Neonatal Congenital Hypothyroidism and Nitrate as an Environmental Pollutant in Isfahan Province During 2010-2013
title_full Spatial Analysis of Neonatal Congenital Hypothyroidism and Nitrate as an Environmental Pollutant in Isfahan Province During 2010-2013
title_fullStr Spatial Analysis of Neonatal Congenital Hypothyroidism and Nitrate as an Environmental Pollutant in Isfahan Province During 2010-2013
title_full_unstemmed Spatial Analysis of Neonatal Congenital Hypothyroidism and Nitrate as an Environmental Pollutant in Isfahan Province During 2010-2013
title_short Spatial Analysis of Neonatal Congenital Hypothyroidism and Nitrate as an Environmental Pollutant in Isfahan Province During 2010-2013
title_sort spatial analysis of neonatal congenital hypothyroidism and nitrate as an environmental pollutant in isfahan province during 2010-2013
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564903/
https://www.ncbi.nlm.nih.gov/pubmed/26425331
http://dx.doi.org/10.4103/2008-7802.162952
work_keys_str_mv AT mehrnejatneda spatialanalysisofneonatalcongenitalhypothyroidismandnitrateasanenvironmentalpollutantinisfahanprovinceduring20102013
AT yazdanpanahhojatollah spatialanalysisofneonatalcongenitalhypothyroidismandnitrateasanenvironmentalpollutantinisfahanprovinceduring20102013
AT fadaeinobarireza spatialanalysisofneonatalcongenitalhypothyroidismandnitrateasanenvironmentalpollutantinisfahanprovinceduring20102013
AT hashemipourmahin spatialanalysisofneonatalcongenitalhypothyroidismandnitrateasanenvironmentalpollutantinisfahanprovinceduring20102013
AT maracymohammadreza spatialanalysisofneonatalcongenitalhypothyroidismandnitrateasanenvironmentalpollutantinisfahanprovinceduring20102013
AT moafimohammad spatialanalysisofneonatalcongenitalhypothyroidismandnitrateasanenvironmentalpollutantinisfahanprovinceduring20102013
AT mousavianzahra spatialanalysisofneonatalcongenitalhypothyroidismandnitrateasanenvironmentalpollutantinisfahanprovinceduring20102013