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Geographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009–2011

Few analyses in the United States have examined geographic variation and socioeconomic disparities in amyotrophic lateral sclerosis (ALS) incidence, because of lack of population-based incidence data. In this analysis, we used population-based ALS data to identify whether ALS incidence clusters geog...

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Autores principales: Henry, Kevin A., Fagliano, Jerald, Jordan, Heather M., Rechtman, Lindsay, Kaye, Wendy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564938/
https://www.ncbi.nlm.nih.gov/pubmed/26041711
http://dx.doi.org/10.1093/aje/kwv095
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author Henry, Kevin A.
Fagliano, Jerald
Jordan, Heather M.
Rechtman, Lindsay
Kaye, Wendy E.
author_facet Henry, Kevin A.
Fagliano, Jerald
Jordan, Heather M.
Rechtman, Lindsay
Kaye, Wendy E.
author_sort Henry, Kevin A.
collection PubMed
description Few analyses in the United States have examined geographic variation and socioeconomic disparities in amyotrophic lateral sclerosis (ALS) incidence, because of lack of population-based incidence data. In this analysis, we used population-based ALS data to identify whether ALS incidence clusters geographically and to determine whether ALS risk varies by area-based socioeconomic status (SES). This study included 493 incident ALS cases diagnosed (via El Escorial criteria) in New Jersey between 2009 and 2011. Geographic variation and clustering of ALS incidence was assessed using a spatial scan statistic and Bayesian geoadditive models. Poisson regression was used to estimate the associations between ALS risk and SES based on census-tract median income while controlling for age, sex, and race. ALS incidence varied across and within counties, but there were no statistically significant geographic clusters. SES was associated with ALS incidence. After adjustment for age, sex, and race, the relative risk of ALS was significantly higher (relative risk (RR) = 1.37, 95% confidence interval (CI): 1.02, 1.82) in the highest income quartile than in the lowest. The relative risk of ALS was significantly lower among blacks (RR = 0.57, 95% CI: 0.39, 0.83) and Asians (RR = 0.63, 95% CI: 0.41, 0.97) than among whites. Our findings suggest that ALS incidence in New Jersey appears to be associated with SES and race.
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spelling pubmed-45649382015-09-15 Geographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009–2011 Henry, Kevin A. Fagliano, Jerald Jordan, Heather M. Rechtman, Lindsay Kaye, Wendy E. Am J Epidemiol ORIGINAL CONTRIBUTIONS Few analyses in the United States have examined geographic variation and socioeconomic disparities in amyotrophic lateral sclerosis (ALS) incidence, because of lack of population-based incidence data. In this analysis, we used population-based ALS data to identify whether ALS incidence clusters geographically and to determine whether ALS risk varies by area-based socioeconomic status (SES). This study included 493 incident ALS cases diagnosed (via El Escorial criteria) in New Jersey between 2009 and 2011. Geographic variation and clustering of ALS incidence was assessed using a spatial scan statistic and Bayesian geoadditive models. Poisson regression was used to estimate the associations between ALS risk and SES based on census-tract median income while controlling for age, sex, and race. ALS incidence varied across and within counties, but there were no statistically significant geographic clusters. SES was associated with ALS incidence. After adjustment for age, sex, and race, the relative risk of ALS was significantly higher (relative risk (RR) = 1.37, 95% confidence interval (CI): 1.02, 1.82) in the highest income quartile than in the lowest. The relative risk of ALS was significantly lower among blacks (RR = 0.57, 95% CI: 0.39, 0.83) and Asians (RR = 0.63, 95% CI: 0.41, 0.97) than among whites. Our findings suggest that ALS incidence in New Jersey appears to be associated with SES and race. Oxford University Press 2015-09-15 2015-06-03 /pmc/articles/PMC4564938/ /pubmed/26041711 http://dx.doi.org/10.1093/aje/kwv095 Text en © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle ORIGINAL CONTRIBUTIONS
Henry, Kevin A.
Fagliano, Jerald
Jordan, Heather M.
Rechtman, Lindsay
Kaye, Wendy E.
Geographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009–2011
title Geographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009–2011
title_full Geographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009–2011
title_fullStr Geographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009–2011
title_full_unstemmed Geographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009–2011
title_short Geographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009–2011
title_sort geographic variation of amyotrophic lateral sclerosis incidence in new jersey, 2009–2011
topic ORIGINAL CONTRIBUTIONS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564938/
https://www.ncbi.nlm.nih.gov/pubmed/26041711
http://dx.doi.org/10.1093/aje/kwv095
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