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CtIP tetramer assembly is required for DNA-end resection and repair

Mammalian CtIP protein plays major roles in DNA double-strand break (DSB) repair. While it is well-established that CtIP promotes DNA-end resection in preparation for homology-dependent DSB repair, the molecular basis for this function remains unknown. Here we show by biophysical and X-ray crystallo...

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Detalles Bibliográficos
Autores principales:	Davies, Owen R., Forment, Josep V., Sun, Meidai, Belotserkovskaya, Rimma, Coates, Julia, Galanty, Yaron, Demir, Mukerrem, Morton, Christopher R., Rzechorzek, Neil J., Jackson, Stephen P., Pellegrini, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564947/ https://www.ncbi.nlm.nih.gov/pubmed/25558984 http://dx.doi.org/10.1038/nsmb.2937

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