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The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity

BACKGROUND: Deleted in Liver Cancer 1 (Dlc1) is a tumor suppressor gene, which maps to human chromosome 8p21-22 and is found frequently deleted in many cancers including breast cancer. The promoter of the remaining allele is often found methylated. The Dlc1 gene encodes a RhoGAP protein that regulat...

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Detalles Bibliográficos
Autores principales:	Basak, Pratima, Dillon, Rachelle, Leslie, Heather, Raouf, Afshin, Mowat, Michael R. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565020/ https://www.ncbi.nlm.nih.gov/pubmed/26353792 http://dx.doi.org/10.1186/s12885-015-1642-x

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