Cargando…

Concomitant administration of sGC stimulators with common classes of anti-hypertensive agents results in increased efficacy in spontaneously hypertensive rats

Detalles Bibliográficos
Autores principales:	Germano, Peter, Tobin, Jenny, Jefferson, Robert, Shea, Courtney, Smith, Adaline, Jamie Im, G-Yoon, Sheppeck, James, Wakefield, James, Sykes, Kristie, Ribadeneira, Maria, Rivers, Samuel, Masferrer, Jaime
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Meeting Abstract
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565123/ http://dx.doi.org/10.1186/2050-6511-16-S1-A54

Ejemplares similares

IWP-121: a novel sGC stimulator that reduces blood pressure and exhibits anti-fibrotic and anti-inflammatory activities in the Dahl Salt-Sensitive rat model
por: Shea, Courtney, et al.
Publicado: (2015)

Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease
por: Zimmer, Daniel P., et al.
Publicado: (2020)

Genetic modifiers of hypertension in sGC-deficient mice
por: Buys, Emmanuel
Publicado: (2013)

SGLT2 inhibition potentiates the cardiovascular, renal, and metabolic effects of sGC stimulation in hypertensive rats with prolonged exposure to high-fat diet
por: Reverte, Virginia, et al.
Publicado: (2022)

Structural insights into sGC
por: Akker, Focco van den, et al.
Publicado: (2009)

Treatment of pediatric pulmonary arterial hypertension: A focus on the NO‐sGC‐cGMP pathway
por: Beghetti, Maurice, et al.
Publicado: (2019)

The sGC stimulator BAY 41-8543 in a rat model of hypertension-induced heart failure
por: Haase, N, et al.
Publicado: (2015)

sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension
por: Vogel, Julia, et al.
Publicado: (2021)

Age- and Hypertension-Related Changes in NOS/NO/sGC-Derived Vasoactive Control of Rat Thoracic Aortae
por: Berenyiova, Andrea, et al.
Publicado: (2022)

Molecular aspects of sGC regulation
por: Marletta, Michael A, et al.
Publicado: (2011)

Targeting native and apo-sGC
por: Struthers, Mary, et al.
Publicado: (2013)

sGC redox regulation and asthma
por: Stuehr, Dennis J, et al.
Publicado: (2015)

Cardioprotective effects in aged spontaneously hypertensive rats due to chronic stimulation/activation of sGC without hypotension
por: Jones, Emma S, et al.
Publicado: (2009)

New clinical results with sGC stimulators
por: Behr, Jürgen
Publicado: (2011)

Synthesis and evaluation of bifunctional sGC regulators
por: Chrominski, Mikolaj, et al.
Publicado: (2013)

Conformational changes involved in sGC activation
por: Marletta, Michael A, et al.
Publicado: (2013)

The treatment with sGC stimulator improves survival of hypertensive rats in response to volume-overload induced by aorto-caval fistula
por: Gawrys, Olga, et al.
Publicado: (2023)

sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH
por: Hall, Katherine C., et al.
Publicado: (2019)

Lack of correlation between sGC subunit expression and sGC activity in cerebral development is due to non-heterodimerizing subunits in vivo
por: Haase, Nadine, et al.
Publicado: (2009)

A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide
por: Wittmann, Christine, et al.
Publicado: (2015)

Synergistic mutations in soluble guanylyl cyclase (sGC) reveal a key role for interfacial regions in the sGC activation mechanism
por: Childers, Kenneth C., et al.
Publicado: (2019)

A molecular view of the regulation of sGC activity
por: Marletta, Michael A, et al.
Publicado: (2009)

Structural insights into sGC activation by different activators
por: van den Akker, Focco, et al.
Publicado: (2011)

The clinical development of sGC modulators, riociguat and vericiguat
por: Misselwitz, Frank
Publicado: (2015)

New vitamin B(12) derivatives activates sGC
por: Gryko, Dorota, et al.
Publicado: (2011)

Gemfibrozil as a potential heme-independent sGC activator
por: Sobolevsky, Michael, et al.
Publicado: (2011)

Comparison of different vasodilators, endothelin antagonist, PDE5 inhibitior and sGC stimulators, in an animal model of secondary pulmonary hypertension: effects on “desaturation”
por: Becker, Eva Maria, et al.
Publicado: (2011)

Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways
por: Lee, Mei-Yueh, et al.
Publicado: (2016)

sGC activators and stimulators attenuate ischemia/reperfusion injury of the lung
por: Egemnazarov, Bakytbek, et al.
Publicado: (2009)

Phenotypes of sGC mutant mice in basic conditions, disease and shock
por: Brouckaert, Peter, et al.
Publicado: (2009)

Inhaled nitric oxide: an sGC-dependent IOP lowering agent
por: Lieb, Wolfgang S, et al.
Publicado: (2015)

Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator
por: Kolijn, Detmar, et al.
Publicado: (2020)

Genetic silencing of sGC β1 in cancer: role of epigenetic regulation
por: Sotolongo, Alex, et al.
Publicado: (2013)

Is Innervation of the Neuromuscular Junction at the Diaphragm Modulated by sGC/cGMP Signaling?
por: Lukáčová, Nadežda, et al.
Publicado: (2020)

sGC Activity and Regulation of Blood Flow in a Zebrafish Model System
por: Vishnolia, Krishan K., et al.
Publicado: (2021)

Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO
por: de la Fuente-Alonso, Andrea, et al.
Publicado: (2021)

sGC Stimulation Saves the Diabetic Heart: Red Blood Cells to the Rescue
por: Papapetropoulos, Andreas, et al.
Publicado: (2023)

Inflammation in the Human Periodontium Induces Downregulation of the α(1)- and β(1)-Subunits of the sGC in Cementoclasts
por: Korkmaz, Yüksel, et al.
Publicado: (2021)

Primary response of the sGC heme binding domain to the cleavage of the Fe-His bond
por: Zhang, Huali, et al.
Publicado: (2008)

Mechanisms driving heme insertion into apo-sGC during its maturation in cells
por: Stuehr, Dennis, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_jrom6ku2oeqmhjpurbrh3iq5v1