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Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies
BACKGROUND: While the discovery of new drugs is a complex, lengthy and costly process, identifying new uses for existing drugs is a cost-effective approach to therapeutic discovery. Connectivity mapping integrates gene expression profiling with advanced algorithms to connect genes, diseases and smal...
Autores principales: | Wen, Qing, O'Reilly, Paul, Dunne, Philip D, Lawler, Mark, Van Schaeybroeck, Sandra, Salto-Tellez, Manuel, Hamilton, Peter, Zhang, Shu-Dong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565135/ https://www.ncbi.nlm.nih.gov/pubmed/26356760 http://dx.doi.org/10.1186/1752-0509-9-S5-S4 |
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