Cargando…
Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID
AID (Activation Induced Deaminase) deaminates cytosines in DNA to initiate immunoglobulin gene diversification and to reprogram CpG methylation in early development. AID is potentially highly mutagenic, and it causes genomic instability evident as translocations in B cell malignancies. Here we show...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565580/ https://www.ncbi.nlm.nih.gov/pubmed/26355458 http://dx.doi.org/10.1371/journal.pgen.1005411 |