Cargando…
Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise
The myocardial response to exercise is an adaptive mechanism that permits the heart to maintain cardiac output via improved cardiac function and development of hypertrophy. There are many overlapping mechanisms via which this occurs with calcium handling being a crucial component of this process. Ou...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565583/ https://www.ncbi.nlm.nih.gov/pubmed/26356305 http://dx.doi.org/10.1371/journal.pone.0136901 |
_version_ | 1782389594509017088 |
---|---|
author | Naticchioni, Mindi Karani, Rajiv Smith, Margaret A. Onusko, Evan Robbins, Nathan Jiang, Min Radzyukevich, Tatiana Fulford, Logan Gao, Xu Apel, Ryan Heiny, Judith Rubinstein, Jack Koch, Sheryl E. |
author_facet | Naticchioni, Mindi Karani, Rajiv Smith, Margaret A. Onusko, Evan Robbins, Nathan Jiang, Min Radzyukevich, Tatiana Fulford, Logan Gao, Xu Apel, Ryan Heiny, Judith Rubinstein, Jack Koch, Sheryl E. |
author_sort | Naticchioni, Mindi |
collection | PubMed |
description | The myocardial response to exercise is an adaptive mechanism that permits the heart to maintain cardiac output via improved cardiac function and development of hypertrophy. There are many overlapping mechanisms via which this occurs with calcium handling being a crucial component of this process. Our laboratory has previously found that the stretch sensitive TRPV2 channels are active regulators of calcium handling and cardiac function under baseline conditions based on our observations that TRPV2-KO mice have impaired cardiac function at baseline. The focus of this study was to determine the cardiac function of TRPV2-KO mice under exercise conditions. We measured skeletal muscle at baseline in WT and TRPV2-KO mice and subjected them to various exercise protocols and measured the cardiac response using echocardiography and molecular markers. Our results demonstrate that the TRPV2-KO mouse did not tolerate forced exercise although they became increasingly exercise tolerant with voluntary exercise. This occurs as the cardiac function deteriorates further with exercise. Thus, our conclusion is that TRPV2-KO mice have impaired cardiac functional response to exercise. |
format | Online Article Text |
id | pubmed-4565583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45655832015-09-18 Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise Naticchioni, Mindi Karani, Rajiv Smith, Margaret A. Onusko, Evan Robbins, Nathan Jiang, Min Radzyukevich, Tatiana Fulford, Logan Gao, Xu Apel, Ryan Heiny, Judith Rubinstein, Jack Koch, Sheryl E. PLoS One Research Article The myocardial response to exercise is an adaptive mechanism that permits the heart to maintain cardiac output via improved cardiac function and development of hypertrophy. There are many overlapping mechanisms via which this occurs with calcium handling being a crucial component of this process. Our laboratory has previously found that the stretch sensitive TRPV2 channels are active regulators of calcium handling and cardiac function under baseline conditions based on our observations that TRPV2-KO mice have impaired cardiac function at baseline. The focus of this study was to determine the cardiac function of TRPV2-KO mice under exercise conditions. We measured skeletal muscle at baseline in WT and TRPV2-KO mice and subjected them to various exercise protocols and measured the cardiac response using echocardiography and molecular markers. Our results demonstrate that the TRPV2-KO mouse did not tolerate forced exercise although they became increasingly exercise tolerant with voluntary exercise. This occurs as the cardiac function deteriorates further with exercise. Thus, our conclusion is that TRPV2-KO mice have impaired cardiac functional response to exercise. Public Library of Science 2015-09-10 /pmc/articles/PMC4565583/ /pubmed/26356305 http://dx.doi.org/10.1371/journal.pone.0136901 Text en © 2015 Naticchioni et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Naticchioni, Mindi Karani, Rajiv Smith, Margaret A. Onusko, Evan Robbins, Nathan Jiang, Min Radzyukevich, Tatiana Fulford, Logan Gao, Xu Apel, Ryan Heiny, Judith Rubinstein, Jack Koch, Sheryl E. Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise |
title | Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise |
title_full | Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise |
title_fullStr | Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise |
title_full_unstemmed | Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise |
title_short | Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise |
title_sort | transient receptor potential vanilloid 2 regulates myocardial response to exercise |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565583/ https://www.ncbi.nlm.nih.gov/pubmed/26356305 http://dx.doi.org/10.1371/journal.pone.0136901 |
work_keys_str_mv | AT naticchionimindi transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise AT karanirajiv transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise AT smithmargareta transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise AT onuskoevan transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise AT robbinsnathan transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise AT jiangmin transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise AT radzyukevichtatiana transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise AT fulfordlogan transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise AT gaoxu transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise AT apelryan transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise AT heinyjudith transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise AT rubinsteinjack transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise AT kochsheryle transientreceptorpotentialvanilloid2regulatesmyocardialresponsetoexercise |