The Parkinson’s Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway

Leucine-rich repeat kinase 2 (LRRK2) is a key molecule in the pathogenesis of familial and idiopathic Parkinson’s disease (PD). We have identified two novel LRRK2-associated proteins, a HECT-type ubiquitin ligase, HERC2, and an adaptor-like protein with six repeated Neuralized domains, NEURL4. LRRK2...

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Detalles Bibliográficos
Autores principales: Imai, Yuzuru, Kobayashi, Yoshito, Inoshita, Tsuyoshi, Meng, Hongrui, Arano, Taku, Uemura, Kengo, Asano, Takeshi, Yoshimi, Kenji, Zhang, Chang-Liang, Matsumoto, Gen, Ohtsuka, Toshiyuki, Kageyama, Ryoichiro, Kiyonari, Hiroshi, Shioi, Go, Nukina, Nobuyuki, Hattori, Nobutaka, Takahashi, Ryosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565672/
https://www.ncbi.nlm.nih.gov/pubmed/26355680
http://dx.doi.org/10.1371/journal.pgen.1005503

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