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Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in vascular endothelial function. Vascular endothelial function is a potent regulator of arterial stiffness, an independent risk factor for cardiovascular disease. However, it is unknown whether LOX-1 is associated with ar...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
the Society for Free Radical Research Japan
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566029/ https://www.ncbi.nlm.nih.gov/pubmed/26388674 http://dx.doi.org/10.3164/jcbn.15-27 |
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author | Otsuki, Takeshi Maeda, Seiji Mukai, Jun Ohki, Makoto Nakanishi, Mamoru Yoshikawa, Toshikazu |
author_facet | Otsuki, Takeshi Maeda, Seiji Mukai, Jun Ohki, Makoto Nakanishi, Mamoru Yoshikawa, Toshikazu |
author_sort | Otsuki, Takeshi |
collection | PubMed |
description | Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in vascular endothelial function. Vascular endothelial function is a potent regulator of arterial stiffness, an independent risk factor for cardiovascular disease. However, it is unknown whether LOX-1 is associated with arterial stiffness. Plasma concentrations of soluble LOX-1 (sLOX-1) and brachial-ankle pulse wave velocity (baPWV, an index of arterial stiffness) were measured in 143 individuals between 51 and 83 years of age. Plasma sLOX-1 concentration was correlated with baPWV (r = 0.288, p = 0.0005). In stepwise regression analysis, plasma sLOX-1 concentration was associated with baPWV, after adjusting for age; body mass index; blood pressure; heart rate; blood levels of cholesterol, triglycerides, glucose, hemoglobin A1c, and insulin; sex; and use of antihypertensives, lipid-lowering agents, and other medications (R(2) = 0.575, p<0.0001). Multiple logistic regression demonstrated that plasma sLOX-1 concentration was independently associated with elevated baPWV (≥14.0 m/s; odds ratio, 1.01; 95% confidence interval, 1.00–1.03; p = 0.03). These results suggest that LOX-1 is associated with arterial stiffness. |
format | Online Article Text |
id | pubmed-4566029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | the Society for Free Radical Research Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-45660292015-09-18 Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals Otsuki, Takeshi Maeda, Seiji Mukai, Jun Ohki, Makoto Nakanishi, Mamoru Yoshikawa, Toshikazu J Clin Biochem Nutr Original Article Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in vascular endothelial function. Vascular endothelial function is a potent regulator of arterial stiffness, an independent risk factor for cardiovascular disease. However, it is unknown whether LOX-1 is associated with arterial stiffness. Plasma concentrations of soluble LOX-1 (sLOX-1) and brachial-ankle pulse wave velocity (baPWV, an index of arterial stiffness) were measured in 143 individuals between 51 and 83 years of age. Plasma sLOX-1 concentration was correlated with baPWV (r = 0.288, p = 0.0005). In stepwise regression analysis, plasma sLOX-1 concentration was associated with baPWV, after adjusting for age; body mass index; blood pressure; heart rate; blood levels of cholesterol, triglycerides, glucose, hemoglobin A1c, and insulin; sex; and use of antihypertensives, lipid-lowering agents, and other medications (R(2) = 0.575, p<0.0001). Multiple logistic regression demonstrated that plasma sLOX-1 concentration was independently associated with elevated baPWV (≥14.0 m/s; odds ratio, 1.01; 95% confidence interval, 1.00–1.03; p = 0.03). These results suggest that LOX-1 is associated with arterial stiffness. the Society for Free Radical Research Japan 2015-09 2015-07-30 /pmc/articles/PMC4566029/ /pubmed/26388674 http://dx.doi.org/10.3164/jcbn.15-27 Text en Copyright © 2015 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Otsuki, Takeshi Maeda, Seiji Mukai, Jun Ohki, Makoto Nakanishi, Mamoru Yoshikawa, Toshikazu Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals |
title | Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals |
title_full | Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals |
title_fullStr | Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals |
title_full_unstemmed | Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals |
title_short | Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals |
title_sort | association between plasma slox-1 concentration and arterial stiffness in middle-aged and older individuals |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566029/ https://www.ncbi.nlm.nih.gov/pubmed/26388674 http://dx.doi.org/10.3164/jcbn.15-27 |
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