Cargando…
Advances in optical imaging for pharmacological studies
Imaging approaches are an essential tool for following up over time representative parameters of in vivo models, providing useful information in pharmacological studies. Main advantages of optical imaging approaches compared to other imaging methods are their safety, straight-forward use and cost-ef...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566037/ https://www.ncbi.nlm.nih.gov/pubmed/26441646 http://dx.doi.org/10.3389/fphar.2015.00189 |
_version_ | 1782389663036604416 |
---|---|
author | Arranz, Alicia Ripoll, Jorge |
author_facet | Arranz, Alicia Ripoll, Jorge |
author_sort | Arranz, Alicia |
collection | PubMed |
description | Imaging approaches are an essential tool for following up over time representative parameters of in vivo models, providing useful information in pharmacological studies. Main advantages of optical imaging approaches compared to other imaging methods are their safety, straight-forward use and cost-effectiveness. A main drawback, however, is having to deal with the presence of high scattering and high absorption in living tissues. Depending on how these issues are addressed, three different modalities can be differentiated: planar imaging (including fluorescence and bioluminescence in vivo imaging), optical tomography, and optoacoustic approaches. In this review we describe the latest advances in optical in vivo imaging with pharmacological applications, with special focus on the development of new optical imaging probes in order to overcome the strong absorption introduced by different tissue components, especially hemoglobin, and the development of multimodal imaging systems in order to overcome the resolution limitations imposed by scattering. |
format | Online Article Text |
id | pubmed-4566037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-45660372015-10-05 Advances in optical imaging for pharmacological studies Arranz, Alicia Ripoll, Jorge Front Pharmacol Pharmacology Imaging approaches are an essential tool for following up over time representative parameters of in vivo models, providing useful information in pharmacological studies. Main advantages of optical imaging approaches compared to other imaging methods are their safety, straight-forward use and cost-effectiveness. A main drawback, however, is having to deal with the presence of high scattering and high absorption in living tissues. Depending on how these issues are addressed, three different modalities can be differentiated: planar imaging (including fluorescence and bioluminescence in vivo imaging), optical tomography, and optoacoustic approaches. In this review we describe the latest advances in optical in vivo imaging with pharmacological applications, with special focus on the development of new optical imaging probes in order to overcome the strong absorption introduced by different tissue components, especially hemoglobin, and the development of multimodal imaging systems in order to overcome the resolution limitations imposed by scattering. Frontiers Media S.A. 2015-09-11 /pmc/articles/PMC4566037/ /pubmed/26441646 http://dx.doi.org/10.3389/fphar.2015.00189 Text en Copyright © 2015 Arranz and Ripoll. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Arranz, Alicia Ripoll, Jorge Advances in optical imaging for pharmacological studies |
title | Advances in optical imaging for pharmacological studies |
title_full | Advances in optical imaging for pharmacological studies |
title_fullStr | Advances in optical imaging for pharmacological studies |
title_full_unstemmed | Advances in optical imaging for pharmacological studies |
title_short | Advances in optical imaging for pharmacological studies |
title_sort | advances in optical imaging for pharmacological studies |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566037/ https://www.ncbi.nlm.nih.gov/pubmed/26441646 http://dx.doi.org/10.3389/fphar.2015.00189 |
work_keys_str_mv | AT arranzalicia advancesinopticalimagingforpharmacologicalstudies AT ripolljorge advancesinopticalimagingforpharmacologicalstudies |