Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast

We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity, and quantitativeness. MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI is safe, noninvasive and offers superb sensit...

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Detalles Bibliográficos
Autores principales: Zheng, Bo, Vazin, Tandis, Goodwill, Patrick W., Conway, Anthony, Verma, Aradhana, Ulku Saritas, Emine, Schaffer, David, Conolly, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566119/
https://www.ncbi.nlm.nih.gov/pubmed/26358296
http://dx.doi.org/10.1038/srep14055
Descripción
Sumario:We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity, and quantitativeness. MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI is safe, noninvasive and offers superb sensitivity, with great promise for clinical translation and quantitative single-cell tracking. Here we report the first MPI cell tracking study, showing 200-cell detection in vitro and in vivo monitoring of human neural graft clearance over 87 days in rat brain.

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