Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast

We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity, and quantitativeness. MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI is safe, noninvasive and offers superb sensit...

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Autores principales: Zheng, Bo, Vazin, Tandis, Goodwill, Patrick W., Conway, Anthony, Verma, Aradhana, Ulku Saritas, Emine, Schaffer, David, Conolly, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566119/
https://www.ncbi.nlm.nih.gov/pubmed/26358296
http://dx.doi.org/10.1038/srep14055
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author Zheng, Bo
Vazin, Tandis
Goodwill, Patrick W.
Conway, Anthony
Verma, Aradhana
Ulku Saritas, Emine
Schaffer, David
Conolly, Steven M.
author_facet Zheng, Bo
Vazin, Tandis
Goodwill, Patrick W.
Conway, Anthony
Verma, Aradhana
Ulku Saritas, Emine
Schaffer, David
Conolly, Steven M.
author_sort Zheng, Bo
collection PubMed
description We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity, and quantitativeness. MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI is safe, noninvasive and offers superb sensitivity, with great promise for clinical translation and quantitative single-cell tracking. Here we report the first MPI cell tracking study, showing 200-cell detection in vitro and in vivo monitoring of human neural graft clearance over 87 days in rat brain.
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spelling pubmed-45661192015-09-15 Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast Zheng, Bo Vazin, Tandis Goodwill, Patrick W. Conway, Anthony Verma, Aradhana Ulku Saritas, Emine Schaffer, David Conolly, Steven M. Sci Rep Article We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity, and quantitativeness. MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI is safe, noninvasive and offers superb sensitivity, with great promise for clinical translation and quantitative single-cell tracking. Here we report the first MPI cell tracking study, showing 200-cell detection in vitro and in vivo monitoring of human neural graft clearance over 87 days in rat brain. Nature Publishing Group 2015-09-11 /pmc/articles/PMC4566119/ /pubmed/26358296 http://dx.doi.org/10.1038/srep14055 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zheng, Bo
Vazin, Tandis
Goodwill, Patrick W.
Conway, Anthony
Verma, Aradhana
Ulku Saritas, Emine
Schaffer, David
Conolly, Steven M.
Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast
title Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast
title_full Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast
title_fullStr Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast
title_full_unstemmed Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast
title_short Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast
title_sort magnetic particle imaging tracks the long-term fate of in vivo neural cell implants with high image contrast
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566119/
https://www.ncbi.nlm.nih.gov/pubmed/26358296
http://dx.doi.org/10.1038/srep14055
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