Cargando…

In Vitro and In Vivo Evaluation of Infestation Deterrents Against Lice

The human head louse is a cosmopolitan ectoparasite and frequently infests many people, particularly school-age children. Due to widespread pyrethroid resistance and the lack of efficient resistance management, there has been a considerable interest in the protection of uninfested people and prevent...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoon, Kyong Sup, Ketzis, Jennifer K., Andrewes, Samuel W., Wu, Christopher S., Honraet, Kris, Staljanssens, Dorien, Rossel, Bart, Marshall Clark, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566486/
https://www.ncbi.nlm.nih.gov/pubmed/26336209
http://dx.doi.org/10.1093/jme/tjv069
_version_ 1782389717022539776
author Yoon, Kyong Sup
Ketzis, Jennifer K.
Andrewes, Samuel W.
Wu, Christopher S.
Honraet, Kris
Staljanssens, Dorien
Rossel, Bart
Marshall Clark, J.
author_facet Yoon, Kyong Sup
Ketzis, Jennifer K.
Andrewes, Samuel W.
Wu, Christopher S.
Honraet, Kris
Staljanssens, Dorien
Rossel, Bart
Marshall Clark, J.
author_sort Yoon, Kyong Sup
collection PubMed
description The human head louse is a cosmopolitan ectoparasite and frequently infests many people, particularly school-age children. Due to widespread pyrethroid resistance and the lack of efficient resistance management, there has been a considerable interest in the protection of uninfested people and prevention of reinfestation by disrupting lice transfer. In this study, two nonclinical model systems (in vitro and in vivo) were used to determine the efficacy of the infestation deterrents, Elimax lotion and Elimax shampoo, against human head lice or poultry chewing lice, respectively. With in vitro assessments, female head lice exhibited significantly higher avoidance responses to hair tufts treated with either of the test formulations, which led to significantly higher ovipositional avoidance when compared with female lice on control hair tufts. Additionally, both formulations were determined to be competent infestation deterrents in a competitive avoidance test in the presence of a known attractant (head louse feces extract). In in vivo assessments using a previously validated poultry model, Elimax shampoo was determined to be an efficacious deterrent against poultry chewing lice within Menopon spp. and Menacanthus spp.
format Online
Article
Text
id pubmed-4566486
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-45664862015-09-15 In Vitro and In Vivo Evaluation of Infestation Deterrents Against Lice Yoon, Kyong Sup Ketzis, Jennifer K. Andrewes, Samuel W. Wu, Christopher S. Honraet, Kris Staljanssens, Dorien Rossel, Bart Marshall Clark, J. J Med Entomol Vector Control, Pest Management, Resistance, Repellents The human head louse is a cosmopolitan ectoparasite and frequently infests many people, particularly school-age children. Due to widespread pyrethroid resistance and the lack of efficient resistance management, there has been a considerable interest in the protection of uninfested people and prevention of reinfestation by disrupting lice transfer. In this study, two nonclinical model systems (in vitro and in vivo) were used to determine the efficacy of the infestation deterrents, Elimax lotion and Elimax shampoo, against human head lice or poultry chewing lice, respectively. With in vitro assessments, female head lice exhibited significantly higher avoidance responses to hair tufts treated with either of the test formulations, which led to significantly higher ovipositional avoidance when compared with female lice on control hair tufts. Additionally, both formulations were determined to be competent infestation deterrents in a competitive avoidance test in the presence of a known attractant (head louse feces extract). In in vivo assessments using a previously validated poultry model, Elimax shampoo was determined to be an efficacious deterrent against poultry chewing lice within Menopon spp. and Menacanthus spp. Oxford University Press 2015-09 2015-06-20 /pmc/articles/PMC4566486/ /pubmed/26336209 http://dx.doi.org/10.1093/jme/tjv069 Text en © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Vector Control, Pest Management, Resistance, Repellents
Yoon, Kyong Sup
Ketzis, Jennifer K.
Andrewes, Samuel W.
Wu, Christopher S.
Honraet, Kris
Staljanssens, Dorien
Rossel, Bart
Marshall Clark, J.
In Vitro and In Vivo Evaluation of Infestation Deterrents Against Lice
title In Vitro and In Vivo Evaluation of Infestation Deterrents Against Lice
title_full In Vitro and In Vivo Evaluation of Infestation Deterrents Against Lice
title_fullStr In Vitro and In Vivo Evaluation of Infestation Deterrents Against Lice
title_full_unstemmed In Vitro and In Vivo Evaluation of Infestation Deterrents Against Lice
title_short In Vitro and In Vivo Evaluation of Infestation Deterrents Against Lice
title_sort in vitro and in vivo evaluation of infestation deterrents against lice
topic Vector Control, Pest Management, Resistance, Repellents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566486/
https://www.ncbi.nlm.nih.gov/pubmed/26336209
http://dx.doi.org/10.1093/jme/tjv069
work_keys_str_mv AT yoonkyongsup invitroandinvivoevaluationofinfestationdeterrentsagainstlice
AT ketzisjenniferk invitroandinvivoevaluationofinfestationdeterrentsagainstlice
AT andrewessamuelw invitroandinvivoevaluationofinfestationdeterrentsagainstlice
AT wuchristophers invitroandinvivoevaluationofinfestationdeterrentsagainstlice
AT honraetkris invitroandinvivoevaluationofinfestationdeterrentsagainstlice
AT staljanssensdorien invitroandinvivoevaluationofinfestationdeterrentsagainstlice
AT rosselbart invitroandinvivoevaluationofinfestationdeterrentsagainstlice
AT marshallclarkj invitroandinvivoevaluationofinfestationdeterrentsagainstlice