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Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users
Adiponectin is an important marker of anthropometric profiles of adipose tissue. However, association of adiponectin and adiposity in HIV mono- and co-infected and hepatitis (HCV) injection drug users (IDUs) has not been elucidated. Therefore, the relationship of total adiponectin levels with anthro...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bioscientifica Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566843/ https://www.ncbi.nlm.nih.gov/pubmed/26306727 http://dx.doi.org/10.1530/EC-15-0071 |
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author | Ndombi, Eric M Budambula, Valentine Webale, Mark K Musumba, Francis O Wesongah, Jesca O Mibei, Erick Ahmed, Aabid A Lihana, Raphael Were, Tom |
author_facet | Ndombi, Eric M Budambula, Valentine Webale, Mark K Musumba, Francis O Wesongah, Jesca O Mibei, Erick Ahmed, Aabid A Lihana, Raphael Were, Tom |
author_sort | Ndombi, Eric M |
collection | PubMed |
description | Adiponectin is an important marker of anthropometric profiles of adipose tissue. However, association of adiponectin and adiposity in HIV mono- and co-infected and hepatitis (HCV) injection drug users (IDUs) has not been elucidated. Therefore, the relationship of total adiponectin levels with anthropometric indices of adiposity was examined in HIV mono-infected (anti-retroviral treatment, ART-naive, n=16 and -experienced, n=34); HCV mono-infected, n=36; HIV and HCV co-infected (ART-naive, n=5 and -experienced, n=13); uninfected, n=19 IDUs; and healthy controls, n=16 from coastal Kenya. Anthropometric indices of adiposity were recorded and total circulating adiponectin levels were measured in serum samples using enzyme-linked immunosorbent assay. Adiponectin levels differed significantly amongst the study groups (P<0.0001). Post-hoc analyses revealed decreased levels in HIV mono-infected ART-naive IDUs in comparison to uninfected IDUs (P<0.05) and healthy controls (P<0.05). However, adiponectin levels were elevated in HCV mono-infected IDUs relative to HIV mono-infected ART-naive (P<0.001) and -experienced (P<0.001) as well as HIV and HCV co-infected ART-naive (P<0.05) IDUs. Furthermore, adiponectin correlated with weight (ρ=0.687; P=0.003) and BMI (ρ=0.598; P=0.014) in HIV mono-infected ART-naive IDUs; waist circumference (ρ=−0.626; P<0.0001), hip (ρ=−0.561; P=0.001) circumference, and bust-to-waist ratio (ρ=0.561; P=0.001) in HIV mono-infected ART-experienced IDUs; waist girth (ρ=0.375; P=0.024) in HCV mono-infected IDUs; and waist-to-hip ratio (ρ=−0.872; P=0.048) in HIV and HCV co-infected ART-naive IDUs. Altogether, these results suggest suppression of adiponectin production in treatment-naive HIV mono-infected IDUs and that circulating adiponectin is a useful surrogate marker of altered adiposity in treatment-naive and -experienced HIV and HCV mono- and co-infected IDUs. |
format | Online Article Text |
id | pubmed-4566843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45668432015-09-14 Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users Ndombi, Eric M Budambula, Valentine Webale, Mark K Musumba, Francis O Wesongah, Jesca O Mibei, Erick Ahmed, Aabid A Lihana, Raphael Were, Tom Endocr Connect Research Adiponectin is an important marker of anthropometric profiles of adipose tissue. However, association of adiponectin and adiposity in HIV mono- and co-infected and hepatitis (HCV) injection drug users (IDUs) has not been elucidated. Therefore, the relationship of total adiponectin levels with anthropometric indices of adiposity was examined in HIV mono-infected (anti-retroviral treatment, ART-naive, n=16 and -experienced, n=34); HCV mono-infected, n=36; HIV and HCV co-infected (ART-naive, n=5 and -experienced, n=13); uninfected, n=19 IDUs; and healthy controls, n=16 from coastal Kenya. Anthropometric indices of adiposity were recorded and total circulating adiponectin levels were measured in serum samples using enzyme-linked immunosorbent assay. Adiponectin levels differed significantly amongst the study groups (P<0.0001). Post-hoc analyses revealed decreased levels in HIV mono-infected ART-naive IDUs in comparison to uninfected IDUs (P<0.05) and healthy controls (P<0.05). However, adiponectin levels were elevated in HCV mono-infected IDUs relative to HIV mono-infected ART-naive (P<0.001) and -experienced (P<0.001) as well as HIV and HCV co-infected ART-naive (P<0.05) IDUs. Furthermore, adiponectin correlated with weight (ρ=0.687; P=0.003) and BMI (ρ=0.598; P=0.014) in HIV mono-infected ART-naive IDUs; waist circumference (ρ=−0.626; P<0.0001), hip (ρ=−0.561; P=0.001) circumference, and bust-to-waist ratio (ρ=0.561; P=0.001) in HIV mono-infected ART-experienced IDUs; waist girth (ρ=0.375; P=0.024) in HCV mono-infected IDUs; and waist-to-hip ratio (ρ=−0.872; P=0.048) in HIV and HCV co-infected ART-naive IDUs. Altogether, these results suggest suppression of adiponectin production in treatment-naive HIV mono-infected IDUs and that circulating adiponectin is a useful surrogate marker of altered adiposity in treatment-naive and -experienced HIV and HCV mono- and co-infected IDUs. Bioscientifica Ltd 2015-08-25 /pmc/articles/PMC4566843/ /pubmed/26306727 http://dx.doi.org/10.1530/EC-15-0071 Text en © 2015 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Research Ndombi, Eric M Budambula, Valentine Webale, Mark K Musumba, Francis O Wesongah, Jesca O Mibei, Erick Ahmed, Aabid A Lihana, Raphael Were, Tom Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users |
title | Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users |
title_full | Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users |
title_fullStr | Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users |
title_full_unstemmed | Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users |
title_short | Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users |
title_sort | serum adiponectin in hiv-1 and hepatitis c virus mono- and co-infected kenyan injection drug users |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566843/ https://www.ncbi.nlm.nih.gov/pubmed/26306727 http://dx.doi.org/10.1530/EC-15-0071 |
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