Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

The acetylenic tricyclic bis(cyanoenone) TBE-31 is a highly potent cysteine targeting compound with a reversible covalent mode of action; its best-characterized target being Kelch-like ECH-associated protein-1 (Keap1), the cellular sensor for oxidants and electrophiles. TBE-31 reacts with cysteines...

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Detalles Bibliográficos
Autores principales: Kostov, Rumen V., Knatko, Elena V., McLaughlin, Lesley A., Henderson, Colin J., Zheng, Suqing, Huang, Jeffrey T.-J., Honda, Tadashi, Dinkova-Kostova, Albena T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567061/
https://www.ncbi.nlm.nih.gov/pubmed/26265043
http://dx.doi.org/10.1016/j.bbrc.2015.08.016

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