A Human Immunodeficiency Virus Controller With a Large Population of CD4(+)CD8(+) Double-Positive T Cells

Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral...

Descripción completa

Detalles Bibliográficos
Autores principales: Durand, Christine M., Buckheit, Robert W., Salgado, Maria, Pohlmeyer, Christopher W., Walker-Sperling, Victoria E., Hegarty, Robert W., Ambinder, Richard F., Blankson, Joel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567082/
https://www.ncbi.nlm.nih.gov/pubmed/26380339
http://dx.doi.org/10.1093/ofid/ofv039
Descripción
Sumario:Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral capacity in HIV-1 controllers, in this case, the CD4(+)CD8(+) T cells did not have strong antiviral activity.

Ejemplares similares