A Human Immunodeficiency Virus Controller With a Large Population of CD4(+)CD8(+) Double-Positive T Cells

Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral...

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Autores principales: Durand, Christine M., Buckheit, Robert W., Salgado, Maria, Pohlmeyer, Christopher W., Walker-Sperling, Victoria E., Hegarty, Robert W., Ambinder, Richard F., Blankson, Joel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567082/
https://www.ncbi.nlm.nih.gov/pubmed/26380339
http://dx.doi.org/10.1093/ofid/ofv039
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author Durand, Christine M.
Buckheit, Robert W.
Salgado, Maria
Pohlmeyer, Christopher W.
Walker-Sperling, Victoria E.
Hegarty, Robert W.
Ambinder, Richard F.
Blankson, Joel N.
author_facet Durand, Christine M.
Buckheit, Robert W.
Salgado, Maria
Pohlmeyer, Christopher W.
Walker-Sperling, Victoria E.
Hegarty, Robert W.
Ambinder, Richard F.
Blankson, Joel N.
author_sort Durand, Christine M.
collection PubMed
description Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral capacity in HIV-1 controllers, in this case, the CD4(+)CD8(+) T cells did not have strong antiviral activity.
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spelling pubmed-45670822015-09-14 A Human Immunodeficiency Virus Controller With a Large Population of CD4(+)CD8(+) Double-Positive T Cells Durand, Christine M. Buckheit, Robert W. Salgado, Maria Pohlmeyer, Christopher W. Walker-Sperling, Victoria E. Hegarty, Robert W. Ambinder, Richard F. Blankson, Joel N. Open Forum Infect Dis Brief Reports Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral capacity in HIV-1 controllers, in this case, the CD4(+)CD8(+) T cells did not have strong antiviral activity. Oxford University Press 2015-03-20 /pmc/articles/PMC4567082/ /pubmed/26380339 http://dx.doi.org/10.1093/ofid/ofv039 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Durand, Christine M.
Buckheit, Robert W.
Salgado, Maria
Pohlmeyer, Christopher W.
Walker-Sperling, Victoria E.
Hegarty, Robert W.
Ambinder, Richard F.
Blankson, Joel N.
A Human Immunodeficiency Virus Controller With a Large Population of CD4(+)CD8(+) Double-Positive T Cells
title A Human Immunodeficiency Virus Controller With a Large Population of CD4(+)CD8(+) Double-Positive T Cells
title_full A Human Immunodeficiency Virus Controller With a Large Population of CD4(+)CD8(+) Double-Positive T Cells
title_fullStr A Human Immunodeficiency Virus Controller With a Large Population of CD4(+)CD8(+) Double-Positive T Cells
title_full_unstemmed A Human Immunodeficiency Virus Controller With a Large Population of CD4(+)CD8(+) Double-Positive T Cells
title_short A Human Immunodeficiency Virus Controller With a Large Population of CD4(+)CD8(+) Double-Positive T Cells
title_sort human immunodeficiency virus controller with a large population of cd4(+)cd8(+) double-positive t cells
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567082/
https://www.ncbi.nlm.nih.gov/pubmed/26380339
http://dx.doi.org/10.1093/ofid/ofv039
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