Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children

The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studie...

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Autores principales: Tiendrebeogo, Regis W., Adu, Bright, Singh, Susheel K., Dziegiel, Morten H., Nébié, Issa, Sirima, Sodiomon B., Christiansen, Michael, Dodoo, Daniel, Theisen, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567085/
https://www.ncbi.nlm.nih.gov/pubmed/26380342
http://dx.doi.org/10.1093/ofid/ofv044
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author Tiendrebeogo, Regis W.
Adu, Bright
Singh, Susheel K.
Dziegiel, Morten H.
Nébié, Issa
Sirima, Sodiomon B.
Christiansen, Michael
Dodoo, Daniel
Theisen, Michael
author_facet Tiendrebeogo, Regis W.
Adu, Bright
Singh, Susheel K.
Dziegiel, Morten H.
Nébié, Issa
Sirima, Sodiomon B.
Christiansen, Michael
Dodoo, Daniel
Theisen, Michael
author_sort Tiendrebeogo, Regis W.
collection PubMed
description The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.
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spelling pubmed-45670852015-09-14 Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children Tiendrebeogo, Regis W. Adu, Bright Singh, Susheel K. Dziegiel, Morten H. Nébié, Issa Sirima, Sodiomon B. Christiansen, Michael Dodoo, Daniel Theisen, Michael Open Forum Infect Dis Brief Reports The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies. Oxford University Press 2015-04-10 /pmc/articles/PMC4567085/ /pubmed/26380342 http://dx.doi.org/10.1093/ofid/ofv044 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Tiendrebeogo, Regis W.
Adu, Bright
Singh, Susheel K.
Dziegiel, Morten H.
Nébié, Issa
Sirima, Sodiomon B.
Christiansen, Michael
Dodoo, Daniel
Theisen, Michael
Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children
title Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children
title_full Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children
title_fullStr Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children
title_full_unstemmed Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children
title_short Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children
title_sort antibody-dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving ghanaian children
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567085/
https://www.ncbi.nlm.nih.gov/pubmed/26380342
http://dx.doi.org/10.1093/ofid/ofv044
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